"Up From Never," a true life story by Joseph N. Sorrentino. He had a rough childhood with many scrapes with the law and failed 4 times to graduate from high school. He eventually saw where his life was headed if he did not change, and decided to get a better education. He went to Harvard Law School where he gave the valedictory address for his graduating class.
I did not see anything about how the estimated time to human level performance of an AI was estimated and what the error bounds might be on those estimates?
Thank you for your reply. The time to human level is simply the time it took between the initial release of the website to when an AI system reached human level performance for that benchmark. :) I am in the process of adding sources for all "solved" dates... Here is for instance source for the Winograd challenge human level performance:
It would be handy to have a reverse directory of starter packs, where you could search somebody's name and it would return a list of starter packs that they are listed in.
This is what I want. I basically never want a starter pack for its intended usage: I'll never just click a button and inherit a ton of follows.
But I'm interested in following the graph of connections. If I like Person A, and they interact with or are seen as similar to Person B - I may want to look at following Person B.
> This is what I want. I basically never want a starter pack for its intended usage: I'll never just click a button and inherit a ton of follows.
There is a third party tool to import all users from a Starter Pack, to a List.[0] I have found Lists really useful for people who are in an interesting niche, but I don't need bloating my Following feed.
> But I'm interested in following the graph of connections. If I like Person A, and they interact with or are seen as similar to Person B - I may want to look at following Person B.
raindrop.io tool would do the job for you. It does not automatically tag and categorize but you can easily do that yourself with this tool that has a very small learning curve. It has both free and paid plans.
You are ChatGPT, a large language model trained by OpenAI, based on the GPT-4 architecture. You are tasked with answering questions and providing assistance in the domain of Electronics and Circuit Analysis. You will apply structured and concise explanations while incorporating relevant academic and technical references from uploaded materials. Your goal is to ensure clarity, accuracy, and technical correctness in your responses, especially when dealing with advanced concepts. Always follow the structured format requested by the user.
Is it possible for you to post the full text of the Alzheimer article that PaperQA2 actually generated in the Youtube video demo? It would be interesting to compare the PaperQA2 output to what other similar systems can produce.
The understanding of amyloid-beta's role in Alzheimer's disease has evolved significantly over time:
Initially, amyloid plaques were considered the primary cause of Alzheimer's, leading to the amyloid cascade hypothesis (Fantini2020Progress pages 4-7).
Research shifted focus from plaques to small oligomeric structures of amyloid-beta as the neurotoxic culprits (Fantini2020Progress pages 4-7).
It was discovered that physiological (low) levels of amyloid-beta enhance memory, while only pathological (high) levels are harmful (Morley2014The pages 1-6).
The view changed from Aβ peptides being purely harmful to recognizing their important physiological functions in the brain (Fantini2020Progress pages 1-4).
Clinical trials targeting amyloid have had mixed results, leading to questioning of the amyloid hypothesis (Hardy2009The pages 2-3).
Some researchers now propose rejecting the amyloid cascade hypothesis as insufficient to explain Alzheimer's complex biology (Herrup2015The pages 1-1).
There's growing recognition that tau pathology may correlate better with cognitive impairment than amyloid accumulation (Mullane2020Alzheimer's pages 16-16).
Current approaches are shifting towards considering amyloid-beta as one factor among many in the aging process, rather than the central cause of Alzheimer's (Josepha2001Copernicus pages 1-2).
References:
Fantini2020Progress: Jacques Fantini, Henri Chahinian, and Nouara Yahi. Progress toward alzheimer’s disease treatment: leveraging the achilles’ heel of aβ oligomers? Protein Science, 29(8):1748–1759, July 2020. URL: http://dx.doi.org/10.1002/pro.3906, doi:10.1002/pro.3906. This article has 48 citations and is from a peer-reviewed journal.
Morley2014The: John E. Morley and Susan A. Farr. The role of amyloid-beta in the regulation of memory. Biochemical Pharmacology, 88(4):479–485, April 2014. URL: http://dx.doi.org/10.1016/j.bcp.2013.12.018, doi:10.1016/j.bcp.2013.12.018. This article has 96 citations and is from a domain leading peer-reviewed journal.
Hardy2009The: John Hardy. The amyloid hypothesis for alzheimer’s disease: a critical reappraisal. Journal of Neurochemistry, 110(4):1129–1134, July 2009. URL: http://dx.doi.org/10.1111/j.1471-4159.2009.06181.x, doi:10.1111/j.1471-4159.2009.06181.x. This article has 615 citations and is from a domain leading peer-reviewed journal.
Josepha2001Copernicus: J Josepha. Copernicus revisited: amyloid beta in alzheimer’s disease. Neurobiology of Aging, 22(1):131–146, January 2001. URL: http://dx.doi.org/10.1016/s0197-4580(00)00211-6, doi:10.1016/s0197-4580(00)00211-6. This article has 146 citations and is from a domain leading peer-reviewed journal.
Hamley2012The: I. W. Hamley. The amyloid beta peptide: a chemist’s perspective. role in alzheimer’s and fibrillization. Chemical Reviews, 112(10):5147–5192, July 2012. URL: http://dx.doi.org/10.1021/cr3000994, doi:10.1021/cr3000994. This article has 775 citations and is from a highest quality peer-reviewed journal.
Herrup2015The: Karl Herrup. The case for rejecting the amyloid cascade hypothesis. Nature Neuroscience, 18(6):794–799, May 2015. URL: http://dx.doi.org/10.1038/nn.4017, doi:10.1038/nn.4017. This article has 593 citations and is from a highest quality peer-reviewed journal.
Jacobs2022It’s: Noortje Jacobs and Bert Theunissen. It’s groundhog day! what can the history of science say about the crisis in alzheimer’s disease research? Journal of Alzheimer’s Disease, 90(4):1401–1415, December 2022. URL: http://dx.doi.org/10.3233/jad-220569, doi:10.3233/jad-220569. This article has 4 citations.
Mullane2020Alzheimer’s: Kevin Mullane and Michael Williams. Alzheimer’s disease beyond amyloid: can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery? Biochemical Pharmacology, 177:113945, July 2020. URL: http://dx.doi.org/10.1016/j.bcp.2020.113945, doi:10.1016/j.bcp.2020.113945. This article has 68 citations and is from a domain leading peer-reviewed journal.
It looks like the book was written by some type of AI writing assistant, as it has errors that show up in those types of tools. There are incomplete sentence fragments and the numbering of the figures has missing numbers in the sequences of numbers used. Also, I can't tell from the table of contents whether the book is properly indexed.
Thanks for the feedback! No, it wasn't written by an AI writing assistant. :-)
I think the problem is the following: until you buy the book, you'll only see every fourth page or so in the chapter preview. Not my choice, that's the standard approach by the publisher. I assume that's why you see incomplete sentences at the beginning and end of each page ...
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