Is it possible for you to post the full text of the Alzheimer article that PaperQA2 actually generated in the Youtube video demo? It would be interesting to compare the PaperQA2 output to what other similar systems can produce.
The understanding of amyloid-beta's role in Alzheimer's disease has evolved significantly over time:
Initially, amyloid plaques were considered the primary cause of Alzheimer's, leading to the amyloid cascade hypothesis (Fantini2020Progress pages 4-7).
Research shifted focus from plaques to small oligomeric structures of amyloid-beta as the neurotoxic culprits (Fantini2020Progress pages 4-7).
It was discovered that physiological (low) levels of amyloid-beta enhance memory, while only pathological (high) levels are harmful (Morley2014The pages 1-6).
The view changed from Aβ peptides being purely harmful to recognizing their important physiological functions in the brain (Fantini2020Progress pages 1-4).
Clinical trials targeting amyloid have had mixed results, leading to questioning of the amyloid hypothesis (Hardy2009The pages 2-3).
Some researchers now propose rejecting the amyloid cascade hypothesis as insufficient to explain Alzheimer's complex biology (Herrup2015The pages 1-1).
There's growing recognition that tau pathology may correlate better with cognitive impairment than amyloid accumulation (Mullane2020Alzheimer's pages 16-16).
Current approaches are shifting towards considering amyloid-beta as one factor among many in the aging process, rather than the central cause of Alzheimer's (Josepha2001Copernicus pages 1-2).
References:
Fantini2020Progress: Jacques Fantini, Henri Chahinian, and Nouara Yahi. Progress toward alzheimer’s disease treatment: leveraging the achilles’ heel of aβ oligomers? Protein Science, 29(8):1748–1759, July 2020. URL: http://dx.doi.org/10.1002/pro.3906, doi:10.1002/pro.3906. This article has 48 citations and is from a peer-reviewed journal.
Morley2014The: John E. Morley and Susan A. Farr. The role of amyloid-beta in the regulation of memory. Biochemical Pharmacology, 88(4):479–485, April 2014. URL: http://dx.doi.org/10.1016/j.bcp.2013.12.018, doi:10.1016/j.bcp.2013.12.018. This article has 96 citations and is from a domain leading peer-reviewed journal.
Hardy2009The: John Hardy. The amyloid hypothesis for alzheimer’s disease: a critical reappraisal. Journal of Neurochemistry, 110(4):1129–1134, July 2009. URL: http://dx.doi.org/10.1111/j.1471-4159.2009.06181.x, doi:10.1111/j.1471-4159.2009.06181.x. This article has 615 citations and is from a domain leading peer-reviewed journal.
Josepha2001Copernicus: J Josepha. Copernicus revisited: amyloid beta in alzheimer’s disease. Neurobiology of Aging, 22(1):131–146, January 2001. URL: http://dx.doi.org/10.1016/s0197-4580(00)00211-6, doi:10.1016/s0197-4580(00)00211-6. This article has 146 citations and is from a domain leading peer-reviewed journal.
Hamley2012The: I. W. Hamley. The amyloid beta peptide: a chemist’s perspective. role in alzheimer’s and fibrillization. Chemical Reviews, 112(10):5147–5192, July 2012. URL: http://dx.doi.org/10.1021/cr3000994, doi:10.1021/cr3000994. This article has 775 citations and is from a highest quality peer-reviewed journal.
Herrup2015The: Karl Herrup. The case for rejecting the amyloid cascade hypothesis. Nature Neuroscience, 18(6):794–799, May 2015. URL: http://dx.doi.org/10.1038/nn.4017, doi:10.1038/nn.4017. This article has 593 citations and is from a highest quality peer-reviewed journal.
Jacobs2022It’s: Noortje Jacobs and Bert Theunissen. It’s groundhog day! what can the history of science say about the crisis in alzheimer’s disease research? Journal of Alzheimer’s Disease, 90(4):1401–1415, December 2022. URL: http://dx.doi.org/10.3233/jad-220569, doi:10.3233/jad-220569. This article has 4 citations.
Mullane2020Alzheimer’s: Kevin Mullane and Michael Williams. Alzheimer’s disease beyond amyloid: can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery? Biochemical Pharmacology, 177:113945, July 2020. URL: http://dx.doi.org/10.1016/j.bcp.2020.113945, doi:10.1016/j.bcp.2020.113945. This article has 68 citations and is from a domain leading peer-reviewed journal.
