Yeah, one-handed use is one of the best things about the iPhone. I switched to Android (Moto X) several months ago from an iPhone 5s. I've been using it one-handed, but it is really painful. By the afternoon I start getting cramps in my thumb. Reaching for the home/keyboard/app menu/etc buttons is just really awkward. And the Moto X is one of the smallest screen Android phones you can get.
Part of it is that Android just isn't designed for one-handed use, but the limited width is a big part of it too.
Part of it is that Android just isn't designed for one-handed use, but the limited width is a big part of it too.