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If by "sex" you mean physical characteristics, it's not what we learn in school books but not all people have only two XX or XY chromosomes. There are other (rare) combinations.

XXY (Klinefelter syndrome), X (Turner syndrome), XXX (Triple X syndrome), XYY (Jacob’s syndrome),

If we think in terms of genes, the situation is further complicated, and hormones also influence the sexual phenotype during fetal development.






There’s also chimeras who can have some XY cells and some XX cells due to the fusion of a male and female fertilized zygotes in the early stages of prenatal development.

Resulting in genetic tests of gender to result in different outcomes depending on which cells are sampled.


There’s a women in the medical literature (I have read the original paper, but can’t lay my hands on it right now) who had multiple children & was discovered to be a 99% XY / 1% XX chimera IIRC.

(edit) This is probably the case paper I was thinking of: https://pmc.ncbi.nlm.nih.gov/articles/PMC2190741/ It was her ovaries that were 99/1% proportions. Other parts of her body had varying levels of mosaicism.


Dr. House treated a patient like this on television over a decade ago.

> XXY (Klinefelter syndrome), X (Turner syndrome), XXX (Triple X syndrome), XYY (Jacob’s syndrome),

While this is true, it's completely irrelevant to the discussion. These conditions are extremely rare - certainly much rarer than gender dysmorphia - and most transgender people are either XX or XY.


Klinefelter syndrome: one to two per 1,000 live birth

Turner syndrome: 1 in 2,000 to 5,000 female births

Triple X syndrome: approximately 1 in 1,000 (female)

Jacob’s syndrome: 1 in 1,000 males

Mosaicism affecting sex determination: 1 in 10,000 to 1 in 50,000

Swyer syndrome: ~1 in 80,000–100,000 births

SRY translocation to X or autosome: ~1 in 25,000–30,000

Androgen Insensitivity Syndrome: 1 in 10,000–50,000

So there are ~0.3% of people who have an unusual sex determination because of genetics. As another poster said that means there are 900,000 people with these conditions in the USA. That's half of the transgender population in the USA.

Yet I agree that does not prove that a significant portion of the transgender population has some genetic variation affecting their sex determination, but definitely it proves that the situation is more complex than many think.


I think the point is the bad-faith effort to erase trans people by asserting that chromosomes are all that matter falls down because obviously there are people running around with unusual chromosomes, so if it was an actual good faith effort they would be defining new (rare) genders to map to these chromosome patterns.

But it’s not good faith, and nobody really believes that chromosomes are the most important definition of gender. It’s just a convenient way to erase trans people.


Nobody serious is claiming that chromosomes are "all that matter", but while you complain about bad-faith efforts to dismiss trans people, you seemingly ignore all of their bad faith efforts to dismiss the importance and reality of sex.

> nobody really believes that chromosomes are the most important definition of gender

I don't understand how you reach this conclusion given the fact that for >99% of the world's people, their gender matches their sex. Who is this "nobody" you speak of?


> I don't understand how you reach this conclusion given the fact that for >99% of the world's people, their gender matches their sex.

What is the significance of this in this context? 100% of the world's people are not lions, does that mean lions don't exist? Some people don't fit neatly into one of the two gender/sex categories. This is scientifically very clear. Why is it important to have hard categories, and why should we legislate that only two categories exist?


> 100% of the world's people are not lions, does that mean lions don't exist

No, 100% of the world's people are not lions, therefore people are not lions.

> people don't fit neatly into one of the two gender/sex categories

Don't conflate gender and sex. All people fit into sex categories because all people have a definite sex, and sex allows for a range of development, even malformed ones.

As for "gender", if it's defined separately from sex, then I don't know what it means because it hasn't been defined. My response was that the vast majority of people don't distinguish between gender/sex, because not only have they never encountered a person where these are distinct, they don't even have any inclination that this is even a thing. That's why I'm confused by the original claim that "nobody" thinks gender comes down to sex. It's just a bizarre claim. If you go to remote tribes in the Amazon, even they think gender and sex are the same.


If you go to remote tribes in the Amazon, you'll find a lot of things modern day society tries to distance itself from, like kidnapping women and beating them until they're docile. You have literally no idea what those people were to think of themselves, given the freedom to do so. Ancient is not the same as good.

https://en.wikipedia.org/wiki/Yanomami_women

Here's some other "ancient" stuff, that can be used to say the opposite of your point: https://en.wikipedia.org/wiki/Two-spirit#Traditional_Indigen...


> Ancient is not the same as good.

Who said otherwise?

> Here's some other "ancient" stuff, that can be used to say the opposite of your point

Yes, native Americans had gay people too, and slightly varying ideas of division of labour. I'm not sure how you think this proves the notion that distinguishing gender and sex is or was some dominant mode of thought.

Just look up transgender history on Wikipedia, literally the opening paragraph says these concepts were invented in the 1950s.


> All people fit into sex categories because all people have a definite sex

I mean, no? Not really? There's a whole history of people who do not have a definite sex, and even then, there are lots of people who appear to have a definite sex but their body is varied massively from the "baseline". Such people are actually more numerous than red-headed people or albinism, within society. All of this is pretty trivial in terms of talking points and very well supported within the encompassing scientific literature, which is why I don't actually feel the need to cite myself here — any introduction to biological psychology, or the general subject of sex/gender, from a biological or sociological view, will very easily get you up to speed on this.


> I mean, no? Not really? There's a whole history of people who do not have a definite sex

Phenotypical sex characteristics do not define sex, and developmental disorders tied to one's sex do not somehow refute one's sex. This talk of "appearances" is exactly the kind of confusion I've been trying to argue against. Biology has a more rigourous definition for sex to avoid exactly these confusions. I do acknowledge that even some biologists have fallen into this trap lately, to our detriment.


> Biology has a more rigourous definition for sex to avoid exactly these confusions.

You're right — here's a semi-old crash course on the whole topic from someone who is actually studied and practiced in the fields of biology and endocrinology: https://imgur.com/a/sciencevet2-on-science-of-gender-qmIiULb

The tl;dr of it is "the bimodal sex distribution model is really bad at a lot of the things we use it for, including predicting results to prescribed medication, or questions about who can give birth". There's some links to actual papers included in the gallery, if you want to follow this up further.

> I do acknowledge that even some biologists have fallen into this trap lately, to our detriment.

From 'knowing people in the field of biology', I can say rather clearly that it's less "some biologists are mistaken/foolish" and more "the majority of biologists who are up to date have decided to revise their beliefs about sex in line with current research".


> Who is this “nobody” you speak of?

That seemed clear? Meaning: there is a population of people who believe gender is abstracted from chromosomes by factors including psychology, and there isn’t a population who claim the believe that gender is 1:1 with chromosomes, but who handwave away the inconvenient < 1% who have a chromosome pattern not mapped to a gender.

Thus, nobody actually believes this. It’s just rhetoric to support an ideological position. There are 8B people on earth; no serious scientific or political position can be built on “if you ignore millions of people who don’t fit”


> Meaning: there is a population of people who believe gender is abstracted from chromosomes by factors including psychology, and there isn’t a population who claim the believe that gender is 1:1 with chromosomes, but who handwave away the inconvenient < 1% who have a chromosome pattern not mapped to a gender. Thus, nobody actually believes this.

I don't think this is true at all. I actually think the population that really believes there is some abstract distinction between gender and sex is relatively a tiny minority, mostly in Western nations.

Edit: >There are 8B people on earth; no serious scientific or political position can be built on “if you ignore millions of people who don’t fit”

To clarify, nobody ignores people who "don't fit". Prior to the spread of transgender awareness, feminism spent a lot of time and effort breaking down stereotypes of what it means to be one sex or the other, in order to allow anyone to express any kind of behaviour or presentation. Taking the position that you have a definite sex regardless of your behaviour or presentation is not "ignoring people who don't fit", it's just recognizing the reality of sex and letting people do what they want, while avoiding a commitment to some completely undefined, fluid notion of "gender".


> I don't think this is true at all. I actually think the population that really believes there is some abstract distinction between gender and sex is relatively a tiny minority, mostly in Western nations.

My understanding is that it is not entirely Western nations and not even all that modern of an idea. https://en.wikipedia.org/wiki/Transgender_history


The opening paragraph literally says, "The modern terms and meanings of transgender, gender, gender identity, and gender role only emerged in the 1950s and 1960s. As a result, opinions vary on how to categorize historical accounts of gender-variant people and identities."

Applying these labels to historical peoples is projection at best. The whole problem with "gender" is that it is either undefined or it has no universal definition, therefore it's meaningless to apply it historically.

To say someone was "gender-varying" at the time is to say they didn't conform to the typical roles associated with their sex in that culture, because there was no notion of gender as we know it, nor is there even a universal definition of gender that we can apply retroactively.


> To say someone was "gender-varying" at the time is to say they didn't conform to the typical roles associated with their sex in that culture[...]

You agree that similar concepts have existed across the globe and in other eras, but want to have a semantic (and convenient for your argument) position that there must be a universal definition for some reason. Are there any societal or cultural concepts that actually do have a universal definition?


I’ve lost interest in the “obv gender equals sex, because sex defines gender” nonsense, but your question is interesting.

Murder comes to mind, but lots of asterisks there (it’s not murder if it’s an honor killing). I’m hard pressed to think of universal mores. Respect for elderly maybe? Or unacceptability of theft?


> You agree that similar concepts have existed across the globe and in other eras, but want to have a semantic (and convenient for your argument) position that there must be a universal definition for some reason.

I don't think I did. I said historians noted that cultures often had roles and duties divided along sex lines, but that some people did not strictly conform to those divisions of labour. In what way does that entail that they had some notion of gender that was abstracted from sex?

> Are there any societal or cultural concepts that actually do have a universal definition?

Law. Government. Trade. Religion. Gods. These all have a definition by which we can look at a system and say, "that was a religious belief", or "that was not a law but a local custom", "this was a deity they worshipped". They're not "universal" in the sense that they are identical in all cultures, they are universal in the sense that you can look at the definition and use that definition to classify cultural characteristics in a meaningful way.

I don't think this is possible with "gender".


The people passing laws and executive orders trying to define "male" and "female" by chromosomes, and thus deny people human rights and/including medical care, are pretty serious.

> the importance and reality of sex.

The what and what? Just because it's "important" to a bunch of extremist religious fundamentalist bigots doesn't mean what's in someone's pants or genes is important to anyone but said someone.

"Reality"? FFS.

Stay in your lane and stop fixating on how other people lead their lives or their self identity. The only degree it affects you is that you're bothering yourself about it.


Those account for a number half the size of trans populations. Are you saying trans is also exceedingly rare and irrelevant, yet they are under attack?

Oh for sure, I didn't mean to employ that sex is itself binary.

> XXY (Klinefelter syndrome), X (Turner syndrome), XXX (Triple X syndrome), XYY (Jacob’s syndrome)

Yes, but all of these conditions are sex-specific, so you're still only one sex or the other.


I am sorry but I am specifically speaking of cases where the phenotype contradicts the genotype. For example, there are cases where an individual has an XY karyotype but develops female traits due to a mutation in the SRY gene.

The word "sex" is ambiguous, do we speak of phenotype (sexual traits/appearance) or genetic characteristics? And if you categorize people by their appearance, how do you categorize people with atypical genitalia (~1/5000)?


[flagged]


> "Everyone has a clear sex, even those with disorders"

I don't think most scientists would agree with you:

https://www.nature.com/news/polopoly_fs/1.16943!/menu/main/t...


That's an opinion piece. Go to the Wikipedia article for "sex" and you'll see it's the very first sentence with plenty of sources.

> Your sex is defined only by the gamete size you produce.

So you have no sex until puberty? After menopause women stop being women? Infertile people also have no sex? What about euneuchs and people who have their ovaries removed?

Your definition seems to create more problems than it solves. It creates billions of new sexless humans.


> So you have no sex until puberty? After menopause women stop being women? Infertile people also have no sex? What about euneuchs and people who have their ovaries removed?

Don't be obtuse, you know perfectly well that's not what it means.


You've made a lot of strong, specific assertions here that contradict my own understanding. For example, you seem to be dismissing some troubling questions regarding sex assignment at birth based on on-the-spot judgment calls. It's probably a good idea for you to provide links to some objective sources.

Just look at Wikipedia page for sex, it's literally the first sentence with sources:

https://en.wikipedia.org/wiki/Sex

The fact that you're confused about this most basic biological fact is exactly what I've been trying to communicate is the problem with gender activists in this space. They've spread considerable misinformation on this topic.

"Sex assigned at birth" is one example of the kind of misinformation I'm talking about. They're equivocating on the term "sex", because doctors are not determining biological sex, but making a determination of legal sex. If they had argued for "gender assigned at birth" for legal purposes, and argued that both sex and gender be determined and recorded (because sex is important medically), there would be no such confusion.


Legality is what we're talking about, though. The government decided, against all reason, that this was something they needed to get involved with. So that means what whatever your definitions of sex and gender are, or whatever definitions the Wikipedia editors are accepting this week, they should not be used to discriminate against any individual, no matter how uncommon their physical traits and sense of identity may be.

I don't know why you think we're talking about legality when this whole thread was about biology. The legal status of one's sex is supposed to follow from biology, but the point is that this is an imperfect process at this time.

As for the legal issues, nobody supports "discrimination" in an abstract sense, but the point is that there's a strong difference of opinion on what counts as "discrimination". If "sense of identity" is all that's needed to trigger some discrimination clause, a quality that cannot be verified physically in any way at this time, then that's a recipe for abuse by bad actors.


Yep. And there's XX people that naturally appear male and XY people that naturally appear female.



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