Easily solved, just overlap by ~40 frames and fade the upscaled last frames of chunk A into the start of chunk B before processing. Editors do tricks like this all the time.
It's not so much that it would be impratical (video streaming, like HLS or MPEG-Dash, requires to chunk videos in pieces of roughly this size) but you'd lose the inter-frame consistency at segments boundaries, and I suspect the resulting video would be flickering at the transition.
It could work for TV or movies if done properly at the scene transition time though.
You could probably mitigate this by using overlapping clips and fading between them. Pretty crude but could be close to unnoticeable, depending on how unstable the technique actually is.