Most likely, spacecraft will rely on power delivered via laser.
If anybody succeeds in working out D-3He fusion, that could work in a spacecraft. (D-T, no.) We could probably scare up enough 3He to use for that, if there weren't too many.
If anybody in the universe is doing interstellar travel I think they would have developed D-D fusion which is somewhat more difficult than D-³He or D-T fusion but probably possible with the a scaled up version of the same machine.
Outside the frost line there is a lot of water and a higher percentage of D relative to H so it seems possible to "live off the land" between the stars without being dependent on starshine. A D-D reactor would produce ³He and T, a lot of those products would burn up in the reactor because the reaction rates are high but it would probably be possible to separate some of those out and use it as a breeder reactor that makes fuel for D-³He and D-T reactors elsewhere. I could picture the big D-D reactor running on a large comet or dwarf planet like Pluto producing D-³He for smaller reactors on spacecraft. (D-T not only produces a lot of neutrons but the T has a half life of 12 or so years and won't last for long journies.)
My guess is that interstellar travelers would develop a lifestyle that works around the frost line, where generic bodies above a certain size have liquid water inside. If they were grabby they might consume Ceres or Pluto but might not really care about dry, idiosyncratic worlds like the Earth and Mars.
Anybody doing interstellar travel should hang their collective head-analog in shame if they haven't mastered aneutronic p-11B fusion yet. (They will need to have figured out how to reflect xrays.)
Having got used to spending interminable ages out in the infinite chill void, they probably have come to prefer being there, so have no desire to roast deep in a stellar gravity well. Their equipment might not even work if warmed too much.
I think parent was talking about space applications.
Anyway unlike fusion, seasonal thermal storage is viable and available now, and will be scaled up in immediate future. Also, with electrical vehicles inducing massive investment into the grid, there will be both pressure and resources to solve the rest.
Since we're talking in present tense that's the remaining 1%.
Moon base can be fine with power beamed from a satellite or plain mirrors in orbit, no atmosphere in the way. Might end up being still cheaper than hauling nuclear reactor there plus all the infra to reliably dump waste heat from it.
It works super-great, collected in the tropics and shipped in chemical form. Before you object to depending on imported liquid fuel, consider that most of the world does already.
The main difference is that literally anybody can make it, not just "oil exporting countries" and "fuel refiners". And, will. And export excess production when local tankage is full.
