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Plenty of unvaccinated (the vast majority, in fact) also experience mild symptoms. It's almost like you've got an unfalsifiable way to always say "it worked!"



> Plenty of unvaccinated (the vast majority, in fact) also experience mild symptoms.

This is true of essentially all diseases except some very very rare exceptions that also tend to burn out very quickly. That's just how disease spread works, mild cases help the virus propagate. It's not like the virus is a mustache twirling villain that wants to murder you, it takes a fairly specific balance to obtain long term survival.

> It's almost like you've got an unfalsifiable way to always say "it worked!"

There's plenty of evidence to support the idea that "it works", and actually quite a lot of evidence to contradict the idea that "it doesn't work". Severe outcomes are blatantly more common, per capita, in people who are not vaccinated. The only way you get to any other conclusion is if you just plain don't trust any evidence presented, in which case there is literally nothing that is falsifiable for you and you may as well believe covid-19 is evil unicorns or something.


> Severe outcomes are blatantly more common, per capita, in people who are not vaccinated.

With omicron? I have not seen any data to support that.


I mean, it's pretty early to be drawing conclusions about this with omicron. Especially since it hit right as people in most of the vaccinated world were hitting 5-6mo since their second shots. That doesn't mean it's "unfalsifiable" it just means it hasn't been yet.

That said, I don't think the null hypothesis is suddenly "vaccines do nothing" for some reason. It's clear enough it spreads more easily but that doesn't suddenly invalidate all prior assumptions about the vaccines' effectiveness against severe outcomes.

Edit: I'm very happy to be proven wrong about this but I feel like people should direct some of these replies more to the person I was replying to? I'm not the one who thinks vaccines do nothing here. :P


It's only too early if, like our public health authorities, you are too bigoted and self-important to trust South African medical scientists because they aren't from a mostly white country. That's my take on why the CDC ignored their scientists, as did the media.

From the very beginning, the South African medical authorities were screaming that this variant was producing far fewer hospitalizations OVERALL (despite higher case numbers) than the delta/alpha did.

But because they are a third world country, and the news media in the West is biased towards bad news, they chose to treat this positive data as suspect. It the SA scientists had talked about how horrible it was, they would have taken it as gospel.

Those of us who were looking at the data knew otherwise.


I thought the issues were more about the younger population than in Europe and the US. And the unknown number of folks that had already been exposed to previous waves. Not the racial makeup of the people living there.


> already been exposed in previous waves

I was amused at the sudden acknowledgement of natural immunity from previous infection in the very publications that have constantly claimed it doesn't exist, the minute it supported their need to keep fear mongering. Same with the younger population point, considering these very organizations have gone out of their way to obfuscate the vast risk stratification by age for most of the pandemic. The terrified 20-somethings wearing respirators in TikTok videos are a result of this.


> I was amused at the sudden acknowledgement of natural immunity from previous infection in the very publications that have constantly claimed it doesn't exist

Can you cite some of these alleged claims?


agreed


> I mean, it's pretty early to be drawing conclusions about this with omicron.

No it's not. Late November was too early. In mid-December we could start drawing conclusions. At this point things are becoming quite clear - we see similar trends everywhere, not just South Africa.


its not early, omicron is declining already in places it hit a few weeks ago


https://www.webmd.com/lung/news/20220105/hospitalization-omi...

"The data suggests that three doses of vaccine provided an estimated 68% drop in the risk of being hospitalized with Omicron compared with people who were unvaccinated."


When you look at individuals, you'll never be able to truly say any treatment "worked" with certainty for virtually anything. It's same with nearly all medical treatments. Humans, very often, get better on their own with time, and time can't ever be rewinded to test the alternative.

The way we know a medical treatment works is by looking at large scale data, controlling for variables, understanding mechanisms of action, and by approaching this science in good faith and not cherry picking data to fit one's own conclusions. There's a concept known as "Number Needed to Treat" that is probably relevant to your concerns here.

Vaccinations have historically been extremely effective for many diseases, and COVID is no exception. It's accurate to say (most) "COVID vaccines are highly effective at preventing severe disease caused by the SARS-CoV-2 viruses". Omicron is so new that it's hard to be certain of anything regarding it right now, but we'll have a better picture in a few weeks. I do know that we're seeing many hospitals get overwhelmed across the US currently, and many medical workers are out sick with a COVID infection.


I have some skeptical family members who like to talk about 3rd party anecdotes. "A nurse told me she saw blah blah blah happen". As you say, stories like this are not a way to know a thing, but I can't get them to understand.

It's like we rolled a die once, and it came up 6, and now we're all forming our own special opinions on whether or not the die is fair. We just can't know. Of course, if someone rolled the dice 30,000 times and reported what they found, that would be great (wink wink).

Instead of using Calc 1 as a filter course, we should use Statistics instead.


Well you can look at this: https://cdn.substack.com/image/fetch/w_1100,c_limit,f_auto,q...

(it's recent data, from NY, so - likely a lot of omicron)


Yet it is predominantly the unvaccinated who are overwhelming hospitals with more severe cases. In NYC it is something like 15x difference -- 30 per 100000 unvaccinated versus 2 per 100000 vaccinated people wind up requiring hospital care. Those may be small numbers, but with omicron clearly being both more contagious and evading prior immunity it rapidly becomes problematic.


It's almost like hospitalization statistics might just back this assertion up with actual irrefutable data.


For crying out loud… Go look up the frickin statistics. The vaccines are very effective.


Really?

See https://vinayprasadmdmph.substack.com/p/vaccine-effectivenes...

Those "frickin" statistics? Or which ones?


From own your link:

> [The] vaccines likely (and evidence shows they) still have great protection against severe disease; …

This exactly what we were talking about above.


Like 15% effective, after 2 jabs, for me personally?


On a personal level it's gonna be either 100% or 0%. You either got severe disease, or you didn't.

You can't extrapolate a population-level percentage from a single data point. Luckily, we've got information on hundreds of thousands of deaths, millions of hospitalizations, and billions of shots.


That doesn't make any sense. If the immune response didn't wane on a personal level we wouldn't be needing any boosters.


You can't get 15% of a case of severe COVID. At a personal level, the vaccine either worked at preventing it, or it didn't. We can compute a population-level probability of those two scenarios for you, but you can't really say "15% effective, after 2 jabs, for me personally".


> You can't get 15% of a case of severe COVID.

Getting Covid or not is binary, yes, but the severity of the disease is on a spectrum. I can surely get a 15% less severe disease thanks to a 4-5 month old vaccination. Just like the severity of the disease depends on the viral load you're exposed to.

Of course there's no way of knowing what the exact percentage is for me personally, so in that sense you're right - it's just an average. But it's surely indicative, which is why you should be getting boosters after a specific amount of time, if you're in a risk group.


"Plenty of unvaccinated (the vast majority, in fact) also experience mild symptoms. It's almost like you've got an unfalsifiable way to always say "it worked!""

Yes, it's called 'Science'.

The vaccine absolutely helps to reduce symptoms, hospitalizations and death, even 5 months in.

There are millions of Omicron cases around the world measure up against various vaccinated and unvaccinated populations.


Yeah we have this thing called a clinical trial. I volunteered in it. Did you?




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