On: SARS-CoV-2 variant A.30 is heavily mutated and eva...

[323]

Why not just update the vaccine with the corresponding sequence from the Delta variant? Isn't the Delta variant today a better baseline than the ancestral virus?

Or do a mix - first shot ancestral, second shot Delta.

[nextos → 323]

I think this is the logical thing to do, but now there are two new roadblocks clinical trials have to face:

* It's hard to recruit non-vaccinated participants

* There will be safety issues to address on people that have received multiple shots and / or designed against different strains

[dolni → nextos]

What are the safety issues surrounding multiple shots or mixed vaccines?