So life as a system benefits from the randomness — but inevitableness — of death, is how I interpret that. Benefits as in, key to its continual perpetuation.
“I'm really not that fussy — I think it's more important to make the best use of what you have. I don't like to walk into a studio, lay down the law, and say, 'I must have this, otherwise I cannot continue with the session.' I'm not like that. I prefer to be more, 'What have you got? Let's see what we can do with that.' I hate spending inordinate amounts of time just playing with a sound, trying different pieces of equipment, and different mics and that stuff. Let's get the job done. Let's make a record. The whole process of recording is one big experiment in itself." - Alan Parsons
I am in the camp that sees themselves getting rid of a smart phone in the future. Right now I've been on the "defanged iPhone" warpath, whittling down my apps to just the necessities. It's been working well, perhaps made easier by giving up social media and news years ago (feeds are harder...I've managed a 1+yr HN fasts a few times, but get sucked back in because of how intellectually stimulating it can be here).
I really want to like this phone, and applaud what they are doing. But...it's still a "phone". Aside from the obvious, how is this fundamentally different (or better) than a defanged iPhone/smartphone? When are we going to rethink this problem of how we integrate networked technology into our daily lives in a way that's healthier for us?
As a hobby ceramicist, I must acknowledge a certain amount of grumpiness borne from what the talc allegations have done to our niche community.
Talc is used extensively in low-mid fire clay bodies as well as an additive to increase plasticity (makes clay easier to work with), and is an excellent source of MgO for fluxing glazes. In short, it's a great material to have in our cabinet [1]. But now there are essentially no more talc sources in the US and the ripple effect seen in our suppliers and manufactures has been a big shock (we are ever at the mercy of big industry!).
But I honestly just don't get the link to ovarian cancer. Chronic exposure to asbestos causing lung cancer, sure, if it were present in talc in high amounts (which is somewhat dubious in the case of talcum powder). Ultimately I have to conclude that J&J, with all of its billions of dollars and army of lawyers, couldn't find a way out of this. So either the research is dated and needs to be reviewed because there is something going on with talc that we don't understand (unlikely, imho), or I'm left speculating that there is something else motivating them to avoid closer scrutiny of their products.
J&J is winning virtually all of the suits that go to trial; it's just the ones they are losing end up with multi-billion dollar jury awards. A jury trial is not a quest for scientific truth, and a jury doesn't need to explain itself - the plaintiff lawyers (search your junk mail folder for the word "talc" to see what a great bunch they are) are going to keep rolling the dice in search of a sympathetic jury.
> But I honestly just don't get the link to ovarian cancer.
What does that mean and what does it signify? Do you know enough about cancer, microbiology, the female reproductive system, etc. that you would 'get' it and that you trust your intuition?
I don't 'get' much of advanced mathematics, but that doesn't at all invalidate it in my mind, or represent evidence to others.
Is your post more than, 'I kinda wish I didn't know the facts here' - a human reaction to bad news.
Mesothelioma is not a "real" cancer in the traditional sense.
Your body has no way to expel fine asbestos fibers, and so they collect in your lungs and shred up the insides. When your body tries to respond by healing, it instead forms growths that constantly re-cut and heal themselves. So it's a type of cancer, but it's unique in that it's not based on malformed DNA.
So the idea that just being in the presence of asbestos is enough to form self-propagating cancers like it's some sort of radioactive isotope... doesn't make any sense. Asbestos on it's own is completely inert.
It's an improbably claim that requires extraordinary evidence.
You’ve made a logical error here - you can basically say the same about every cancer.
The specific cancers that fit directly into the category you are carving out for mesothelioma are squamous and adénocarcinomas of the oesophagus, gastric mucosa and large bowel; lung cancers and other cancers of the epithelium.
The basic pathological process underlying cancer is cell dysplasia (usually caused by irritation/prolonged inflammation) which leads to metaplasia. Whether this is driven by a de novo mutation in that cell or from an external source is totally irrelevant and mesothelioma is certainly not unique in how it comes to fuck you up
Talc is used medically as a treatment for recurrent pleural effusions. It is introduced into the pleural space and triggers an intensely inflammatory reaction which more or less fuses the pleura together to prevent the accumulation of fluid (pleurodesis).
When a patient who has had a pleurodesis gets an FDG PETCT, they will have intense accumulation of radiotracer for years. It is very inflammatory. Even more so than asbestos.
I wouldn’t want talc anywhere inside my reproductive tract or anywhere inside my body if I could avoid it.
If you buy the chronic inflammation leads to cancer hypothesis, talc leading to cancer is not so far fetched.
Location matters. The immune system reacts differently to foreign bodies depending on what tissue is in contact with it.
Damn near anything you add to the plural space is going to send your immune system into overdrive - the cells that line the plural cavity (mesothelial cells) are programmed to respond a certain way to their environment.
Contrast that with the cell that line your respiratory tract. There are cells that produce mucus, cells with cilia that sweep the mucus away from the lungs. They don't respond with a massive inflammatory reaction to foreign substances like the plural space does (at least not in a healthy human - asthma patients are different).
Same with the reproductive tract, especially the female one. We can insert IUDs into the uterine cavity without a massive inflammatory response.
Your last paper is particularly interesting! Not only the results, but also the disclaimer!
"The authors declare the following competing financial interest(s): J.J.G., W.R.W., and D.W.C. have served as consultants and provided expert testimony in talc and other environmental litigation."
Ok, well good to set the context here.
But lets look at the results of the controls (no talc exposure) where the conclusions are remarkably cryptic, but I think we can figure it out!
The paper looked at tissue samples from ovarian cancer patients - a group of six who reported decades of talc use on their bottom and six who said they didn't use talc.
They used two techniques - polarizing light microscopy (very simple technique to look for polarizing molecules like talc) and then SEM/EDX which uses an electron beam and then measures x-rays emitted to identify exactly what the particles are.
"Polarizing light microscopy, as shown in the table, revealed a range of two to 17 birefringent particles per slide; these values are comparable to the lower end of the polarizing light microscopy results of the exposed patient"
Conclusion: using the same initial technique, we actually see the same particles (suspected talc) in the controls, but "at the lower end of the range for exposed patients". Very vague, but we can conclude they saw suspected talc in the unexposed patients but on the lower end of the range for the exposed. But that means the two groups overlapped in suspected talc particles.
Well, we better confirm those results with another analytical technique to confirm it's talc, right?
"Correlative SEM/EDX of the control tissue blocks showed a total of four talc particles across all patients: two in patient 2 (right ovary) and two in patient 3 (right fallopian tube). Of note, in Supplementary Table 1, both these patients had pelvic surgery more than 30 years prior to their ovarian cancer surgical procedure."
Oh crap! Those are talc particles in the tissue in the people not exposed to talc. Where did it come from? Oh, but it's probably the surgery they underwent prior!
Which on the surface makes sense - gloves, instruments, gauze, needles might have talc particles on them. Hell, all these tissue samples were removed and then handles by a lab as well - a ton of more exposure to talc is possible! In both the test and control subjects.
But anyways, yeah, it was introduced during surgery, that explains why we see talc in the non-exposed controls. But wait!
"Among the five patients in the main study, two had a history of tubal ligation"
Oh man! The patients that did use talc had surgery too! But the article doesn't call out the contradiction - if the reason for the talc in the controls is surgery, and your test subjects also had surgery, then you should find talc too! They just call out the surgery in an attempt to claim that with a tubal ligation, talc should be blocked from moving up the fallopian tubes. They don't even realize they contradicted their own results.
Jesus Christ this is a terrible, terrible paper. Written up and published for the sole purpose of trial lawyers - the authors had made plenty of money testifying to that fact.
Then on top, they do a bunch of hand wavy stuff to explain away the talc in the samples of the non-exposed, but don't realize at the same time they are explaining away the results in the people exposed too.
> They just call out the surgery in an attempt to claim that with a tubal ligation, talc should be blocked from moving up the fallopian tubes. They don't even realize they contradicted their own results.
They did address this and noted that in patients with tubal ligation the talc distribution was different and lymphatic rather than “mechanical” through the fallopian tubes.
Still not sure what your angle is here.
It’s known that talc is inflammatory. It’s literally used with that intention medically. We don’t use powdered latex gloves in the modern day nearly as frequently as before, mostly because of latex allergy but also due to concerns that talc exposure leads to worse peritoneal scarring/adhesions.
The fact that talc is present inside the surgical specimens is bad in and of itself, regardless of how it got there. That implies an environmental cause for the malignancy, a la asbestos or smoking.
> the idea that just being in the presence of asbestos is enough to form self-propagating cancers like it's some sort of radioactive isotope... doesn't make any sense.
It doesn't make sense to you and therefore is worth exploring. At the same time, unless one is an expert then the fact that they don't understand isn't much evidence that it's untrue.
Most people don't understand much about my field of expertise; their lack of knowledge doesn't invalidate most of my field.
My old friend with no history of asbestos exposure, a sysadmin no less, died of mesothelioma last year. I only learnt that yesterday. (We grew apart...)
I spent an hour reading about that cancer. It seems that mesotheliomas without previous known asbestos exposure do occur.
> So it's a type of cancer, but it's unique in that it's not based on malformed DNA.
This is absolutely incorrect.
Several genes are commonly mutated in mesothelioma, and may be prognostic factors. These include primarily BAP1, NF2, and TP53;[63] epidermal growth factor receptor (EGFR) and C-Met, receptor tyrosine kinases can also be altered and overexpressed in many mesotheliomas.
One thing that drives me nuts is that you can’t get pure talc in the US (baby powder has stuff added to it, including oils and fragrance; the oils can screw up plastic, etc over time).
The last time I looked, it was being sold as though it was a controlled substance alongside laboratory grade ethanol, etc.
On the one hand, baby powder causes ovarian cancer (there is evidence that this is true for talc that is not contaminated with asbestos, despite J&J’s long disinformation campaigns).
On the other, if you want to use it in an application where it is perfectly safe, it’s essentially impossible to buy an appropriate product.
Tire talc is still used on light aircraft tire tubes. I stocked up on a bunch, but it still seems to be widely available. Maybe it's fundamentally a different product than the J&J baby stuff...?
> Ultimately I have to conclude, that J&J with all of its billions of dollars and army of lawyers, couldn't find a way out of this.
As I understand it, J&J executives moved to bury data rather than investigating. In addition, J&J specifically targeted minorities proclaiming dubious "benefits" at the same time they were burying anything to the contrary.
Consequently, it doesn't really matter whether there is or isn't a link. The optics are so terrible that J&J is going to lose badly if brought to trial.
This is the whole "silicone breast implants" thing all over. In the end, the silicone implants were not at fault, but the behavior of the responsible company was sufficiently reprehensible that they were going to lose no matter what.
Can you please make your substantive points without snark or crossing into personal attack? You're welcome to share your experience here—we just want to avoid degrading to internet default if possible.
Women were marketed to put this on their labia every day in order to feel "fresh and clean". This is a very dubious benefit given that feminine hygiene products like this tend to cause more irritation and problems than they prevent.
This wasn't about avoiding swamp-ass from working in the hot sun even if my feet concur with you about the effectiveness of talc and the uselessness of cornstarch.
Talc has been used for humans for thousands of years for every purpose imaginable. It's weird to single out a specific single use as being particularly malicious.
Well, it doesn't matter. It's gone for everyone and every use case now.
J&J has left the business, but there are other companies. You probably can’t buy it at the corner store anymore, but it’s available online. I just looked on Amazon and 1 lb is $23.
This is essentially true. Pharma is incredibly expensive (for lots of different reasons), with R&D taking up a huge portion of those costs.
So yes, it's safe to assume that part of the accounting around those published costs in the billions are all of the failed candidates that never even made it to trials (the failure rate varies depending on the area of biology and the type of drug, but it's generally around 9 out of every 10 candidates [1]. By the time you get to trials, that ratio gets even more abysmal).
Disclaimer -- I work for Recursion, a company built around this very problem.
R&D takes lots, but so does compliance --for good reason. But compliance costs a lot of money, directly and indirectly. Lots of people, lots of inefficient processes, etc.
> Under this theory, moms took the brunt of the blame, supposedly for being "cold and distant and detached from their child."
Before the heredity nature of autism was accepted, this was the school of thought (“refrigerator mothers”). But in truth, it’s neurodivergent parents having neurodivergent children, and society punishing the parents (namely mothers) for their inability at providing the “expected” nurturing conditions.
Tied back, atypical behavior.may create neurodivergent conditions, but one would expect children of aurististics to seek less overall care which doesnt support the hypitheses that antibiotics are causing aitism as this thrwad started
This perspective is well received; made a bit serendipitous by the unexpectedness of it (for me).
It came as an insightful thing to think about when linking it to the idea that we, humans, are a just a Darwinian biological system, and the rate at which we accelerated away from the eons in which basic tribalism ruled our pretty static social environment and cognitive real estate, was a giant shock to it.
I kinda love with silly endearment all the neat things we discovered to help our feeble little homunculi try to engage and wrangle it all; feudalism, monarchies, democracy, socialism, communism, cults, religion —- c’mon, you’ve got to give us animals a little credit for being quirky.
But oh!!! When you manage to glimpse at the mass representing the futility!
In terms of gaining success. Artists are chosen by galleries, media reporters based on their story, ie their brand, and how the could be represented to clients, readers. Is there anything interesting to be said or are they just another mfa graduate?
That's why you see the crazy antics of ie a urinal as an artwork, taping a banana to the wall, and the insane art writing that come with an artwork.
A piece of art is not bought for its craftsmanship or what it looks like. It is bought because of the story of the artist, the fact that other people know the artists story, so hanging it on your wall means something. It is part of culture. A Picasso is worth a lot because of its part of art history.
One aspect of Japanese culture that deeply resonates with me is its unique connection to the geographical landscape. It seems intricately woven with the very essence of Japan, a nation shaped by the terrifying reality of earthquakes, tsunamis, typhoons, and volcanoes.
These influences appear to have profound influence on the collective mindset of the people. The constant reminder of impermanence has sculpted a distinctive perspective on life, rendering the cultural tapestry of Japan something that feels intrinsically tied to its specific time and place.
I often reflect on this thought -- Japan could have only ever happened in Japan.
I think this is true of all places, people just tend not to recognize it where they live.
One of my favorite ways to travel is by train or motorcycle over long distances, and just watch how architecture, clothing, styles, layouts, etc change or surprisingly don't change in response to geographical changes.
Both are possible, and both tell you a lot about the people there.
