They're are many downfalls with working remote. In the past year of being remote I've found that it can be very difficult to pick up on the attitude of a co-worker or boss. It also can make difficult conversations not go so well. People will also avoid having to have face to face conversations because they don't like confrontation. I like working remote, but I also think it's important that a "connection" be built with your co-workers and sometimes that just only partially happens over chat and hang outs.