It was my understanding that it wasn't that those things weren't "not supported" but that the drivers will no longer be included with the base install.
Stuff like off-the-wall scsi drivers, or floppy drivers, or serial port mouse support.
You can still download and install the drivers for those things, but they won't be there right away.
I don't know about Windows 10, but the driver model changed significantly with Windows Vista, so XP drivers actually will not work out of the box on newer versions of Windows. So if you're using a really old peripheral that isn't maintained anymore, chances are you won't be able to run it on a modern Windows machine.
I'm curious, assuming physical connections are still possible(i.e. ye olde COM/Serial port), how well do the use of VMs hold up in mission-critical processes such as these?
