I haven't tried this myself. However, there are various threads (eg. [1][2]) on the Kryoflux support forum where people have reported success, and others ([3][4]) that are more mixed. The Kryoflux manual [5] also says its works with an 8" Shugart 851 drive, and that there are firmware options to support 8" drive timings.
According to an answer on [3] an 8" drive needs to be "Shugart compliant", and in [4] it is mentioned that an adapter made by DBIT is needed to convert the 34-pin floppy cable to the 50-pin interface apparently used by 8" drives. The Kryoflux I have wasn't supplied with a 50-pin cable, so that would need to be sourced.
According to an answer on [3] an 8" drive needs to be "Shugart compliant", and in [4] it is mentioned that an adapter made by DBIT is needed to convert the 34-pin floppy cable to the 50-pin interface apparently used by 8" drives. The Kryoflux I have wasn't supplied with a 50-pin cable, so that would need to be sourced.
So, probably doable with some moderate effort...
[1] http://forum.kryoflux.com/viewtopic.php?t=159
[2] http://forum.kryoflux.com/viewtopic.php?t=887
[3] http://forum.kryoflux.com/viewtopic.php?t=706
[4] http://forum.kryoflux.com/viewtopic.php?t=56
[5] http://www.kryoflux.com/?page=download#docs