Think about the alternative. If you're not willing to let anyone get hurt for the sake of principle, the only principle you can ever hold is "don't ever let anyone get hurt for any reason, no matter what". In the first place, that's impossible. In the second, the more you attempt to force people not to get hurt, the worse off you make everyone's lives. We can't all live shut in padded rooms.
Indeed. This is an excellent explanation of exactly how fundamentalism works: everything must reduce and cohere down to a particular set of principles, rather than reacting and adapting to reality with an understanding that the present understanding of morality isn't fixed and is subject to change.
Once you pick a line in the sand you will not budge over, you have maimed your capacity for reason. So yes, the only principle I could ever hold is an impossible one. Fortunately, I do not hold it.