I think it would be interesting to hear more discussion on HN regarding these different types of problems. Just as we can all learn about optimal web promotion strategies, or the right development framework to use, so too should we learn from others about how to identify the right manufacturing partners, how to arrange distribution deals, channel strategies, etc.
I am getting involved in a plastics manufacturing business and reading like crazy to prepare myself for it.
the biggest problem I have is very similar to a technology problem. The engineers love to do design and vetting (ie/ riding the prototype parts) but are not keen on the follow through aspect of finalizing design and going to production to enable sales. Much the same as a technologist who loves to tinker and refactor, but isn't interested in shipping product or doing support.
bicycle parts manufacturing. Manufacturing has quite a different set of headaches.