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The performance hit of a GC is less than the hit of a language that wasn't designed to be compiler-friendly. Scheme or CL will perform better than scripting languages.

You don't need really hard problems before the benefits of a language with macros become obvious. SQL-driven web apps are a lot easier to write if you have macros, for example: http://brl.codesimply.net/brl_4.html#SEC31




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