Ignoring the whole "we'll just cure mortality...how hard can it be?", people tend to go batshit crazy after spending a couple of months in confined conditions looking at the same faces day after day. Think they're going to do better mentally when they look forward to the same for a 100 years.
Then we have to address this newly pinpointed problem - to somehow make people not „go batshit crazy”. Maybe practicing some kind of meditation? I admit that it's not as exciting as some technical overhaul we all expect, but still...