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One thing that isocaloric studies do not show is how chronic consumption of one particular diet or another influences consumption patterns over time. This is by design and is a huge flaw IMO.

Any diet that keeps you just above the limits of starvation is going to show no change in weight gain.

A much more compelling study would be an overfeeding experiment between a high fructose diet, high glucose diet, high protein diet, high fat diet, etc.




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