This is great for that 1 time out of 1,000,000 when you have an ajax call that would benefit from a tool like this. In the overwhelming majority usecase, this oboe.js thing is not going to be a "plug it in, automatically webscale" type of optimization. I'm not trying to rag on the authors of this project, but the wording of this submissions is going to lead noobs to mis understand the benefit. The authors should instead emphasize the usecase where an actual benefit comes out of using this library, instead of just saying "it makes your ajax faster!!"
It should make most calls faster. Exceptions are for small JSON files or on networks that are fast enough there is no streaming effect (the whole file arrives very quickly)
For most sites there'll be some users where it will make it faster (mobile, slow internet) and others that it'll be about the same. If the network is unreliable it should help as well because when the connection drops you don't lose what you already downloaded.