Dota 2 will likely be one of the flagships of this thing. I don't know how well it will work - likely you won't make it to the top of the league with this. But you can be damned well sure that Valve had Dota 2 in mind when they made this, and they will do everything possible to make Dota 2 play nicely on it.
I can last hit OK with a trackball (after some getting used to, thanks to RSI), but edge scrolling is difficult.
With two trackballs, perhaps one of the wheels can be used for moving the screen, and the other for moving the mouse.
They've implemented a "chat-wheel" with common in-game phrases to help with communications as well, which seems to be a perfect fit for controller play.
I just can't wait for the day where I can invite people over, buy an 80" TV, and play Dota 2 split screened on controllers!
