Bill Gates didn't become that rich by thinking "I'll build this software company, sell it and then do what I'm passionate about".
He became successful by following his passion, and was then able to be philanthropic. People who are passionate about saving the world will be far more likely to change the world by focusing on that and use other people's money to do so.
The point is if you're miserable in your job, and you could be doing something else anyway you should change. Which is what makes it different from the other soul destroying examples mentioned. Go back to Maslow's hierarchy of needs and self actualisation. It could be arguably worse to look back on a squandered life when you know it could be different, those who have no opportunity to change their fate do suffer, but in a different way - they aren't the ones causing their misery.
He was still doing philanthrophic stuff well before stepping down, and it was that much easier to do because he'd stuck with making MS a success first. One can have multiple passions in life, and still prioritize attention to each.
The point is if you're miserable in your job, and you could be doing something else anyway you should change. Which is what makes it different from the other soul destroying examples mentioned. Go back to Maslow's hierarchy of needs and self actualisation. It could be arguably worse to look back on a squandered life when you know it could be different, those who have no opportunity to change their fate do suffer, but in a different way - they aren't the ones causing their misery.