Beware, I'm heavily command line oriented, YMMV. I rolled my own management code based on Python and some shell scripts. As a database we are using SimpleDB and this is a very nice combination. We have hundreds of machines, this kind of approach is needed because of the scale of operation.
Besides that there is AWS tools which is a single Perl script, powerful enough the replace a lot of EC2 and S3 operation without any other dependency, I'm using that for shell scripts and manual operations: http://timkay.com/aws/
Besides that there is AWS tools which is a single Perl script, powerful enough the replace a lot of EC2 and S3 operation without any other dependency, I'm using that for shell scripts and manual operations: http://timkay.com/aws/