I'm on a desktop machine. Also using a 22-inch monitor at 1680x1050. I do not maximize my browser window (mybrowserinfo.com tells me my browser dimensions are currently 1112 x 945).
The font size in question looks great to me. I should add I often sit with my head as far as 24 inches away from the monitor.
The font size in question looks great to me. I should add I often sit with my head as far as 24 inches away from the monitor.