I've specified in chrome for click to play on flash which has helped the autoplay videos, as well as blocked a bunch of offenders (meebo) to my hosts file. Couple this with adblock plus and I'm pretty OK with having JS auto-run.
We fixed it on the blog. We still have to address it on the main site. Google's Open Sans looks awesome on OSX and Windows/IE & Firefox. But it's totally busted on Chrome on W7. Go Figure.
w7, chrome (with javascript disabled, adblock, flashblock, etc)