Serious question: what's the point of all these Node.JS frameworks trying to mimic existing web framework functionality? Once you start adding synchronous database access, don't you lose more of the advantages of NodeJS anyway? Seems like all these frameworks appearing are trying to solve a problem already solved.
I've read some of the comments below and it seems there's some form of consensus that Node shines for the websocket.io portion of the web stack. So likely real use cases for NodeJS will using it in conjunction with your regular website?
