I was actually trying out Chandler earlier this week and I found it disappointingly hard to configure, and I'm not normally one to have that be the show stopper (cf occasionally spending 10 hrs figuring out how to build some unixy software and have it interact nicely with some sort of emacs package)
I just end up using Mutt as my MUA and Gmail as my really fancy sorta-half-MDA. To finish it out I have to use something like fetchmail (which is okay), I usually end up using Mutt's built-in imap feature.