The Outlook and Exchange teams stress test their systems with the following Microsoft distribution lists: internz, gmrchat, failboat, lolcats, and bacon
If I was on the Outlook team at MS I'd have made the reply-all button 4x as big, for the lulz.
I am pretty sure with the Office Resource Kit you can disable it company-wide with a group policy, people just fire up Outlook one day and it's gone. No idea why Windows admins don't do that (you can still reply-to-all if you really want to using the Actions menu).