Religion and politics are highly cultural things. Mental health and what is deemed as correct mental health versus abnormal mental health are cultural understandings and not universal norms. I know people like to think they are absolute universal norms but they are not. A culture defines what is considered normal and what is considered abnormal and oftentimes they can associate the abnormal condition to being due to mental health. Western societies which are considered very progressive on this front change their view all the time as their cultural norms change.
So it does change the meaning a lot. Instead of simply screaming at someone that they are mentally defective because they're transgender. Now it becomes a cultural discussion which is underpinned by politics and religion of what is considered normal behavior in your society. The normalcy of societies has had both good and bad repercussions and will continue to do so for some time because none of us are all altruistic all the time.
So it does change the meaning a lot. Instead of simply screaming at someone that they are mentally defective because they're transgender. Now it becomes a cultural discussion which is underpinned by politics and religion of what is considered normal behavior in your society. The normalcy of societies has had both good and bad repercussions and will continue to do so for some time because none of us are all altruistic all the time.