Yes. Studies of nuclear explosion impact effects distinguish between "ground burst" and "air burst" detonations. Ground bursts typically have a smaller overall radius of damage, but do more intense damage at or near ground zero. Air bursts spread their effects across a wider radius, but damage is relatively more evenly distributed. Ground bursts also produce more fallout, since they dig up and irradiate earth and scatter it to the winds.
Reply to 'gcb' who's account is hellbanned, so I can't reply to him directly.
No: Ground bursts cause way more fallout. Air pretty much can not become radioactive no matter how powerful the bomb. But soil can, so it becomes radioactive, then is scattered by the wind.
The fallout from the bomb itself is different and is the same for both - but it's a smaller component, since there isn't that much of it.