Yes, and without understanding how it works, I'm left wondering whether it's even safe to use this way. Will creduce execute mutated versions of the input script, potentially deleting my files or eating my lunch?
C-reduce is meant to... Reduce your files, it would not add stuff that was not there in the first place. Also, I think it's meant to only be run against the "frontend" of most languages, not full execution
While I've used c-reduce before, I've never done it in a way where it could be destructive. However speculating based on what I do know. I think the 2 things I would do would be in the interesting-ness test, grep for already known harmful instructions and force them to be uninteresting (returning 1). And then if I was still unsure of the potential harm of the program and I had to run it to determine if it's interesting or not (segfault or something similar). I think I would hoist the binary/script into a docker container and run it there. That way the log and result can still be checked, but it's access to actual file system is minimized as much as possible.
TLDR; C-Reduce just gives you text to run/compile, if you're worried about things like that sandbox as much as possible.