On: Saturated fat: the making and unmaking of a scient...

[naveen99]

There is a u shape to ldl levels and longevity just like with bmi: https://pmc.ncbi.nlm.nih.gov/articles/PMC4908872/

By the guidelines nunbers, Low is worse than normal, “normal” is low, a little high is protective when you have other morbidities…

[KempyKolibri → naveen99]

Because LDL drops when you have cancer, or a heart attack. That is, the U shape is a result of reverse causation. When you look at longitudinal data there’s no U shape - it’s straight as an arrow. Higher LDL-c -> more heart disease.