I am pessimistic about purely in silico or even in vitro methodd to tackle a problem as complex as aging rates. Improving mouse models to incorporate a high level of genetic diversity is a better first step. This is what our group of resesrchers is doing now. Results are promising and results are also highly dependent in genetics and sex.
Improving the genetic diversity of mouse models doesn't help you when a humans are far more complex, anyway. You may find a universal effect for a mouse, it's still a mouse. You're trying to fix the space shuttle by testing changes on automobiles.
https://pubmed.ncbi.nlm.nih.gov/36173858/
https://pubmed.ncbi.nlm.nih.gov/34666007/
https://pubmed.ncbi.nlm.nih.gov/34552269/