On: Metformin decelerates aging clock in male monkeys

[jokowueu → Gelob]

Much less of an issue with XR and after a few months you won't feel any discomfort

Most annoying thing for me was the metal taste in my mouth for a few months

Had to take it for my reactive hypoglycemia

[altgeek → Gelob]

This is a common side effect. Try the extended-release form, i.e. Glucophage XR.

[leptons → Gelob]

Probably not that common, as my anecdotal ass has been on Metformin for many years and there's been zero side effects. I'm quite regular. In the past I had plenty of stomach/stool issues, but I've found that more fiber in my diet fixed that up nicely.

[zamadatix → leptons]

I don't know about shitting your pants levels bad but gastrointestinal side effects are very common with Metformin, on the order of ~30% taking it will have... quite a time at the start (I was definitely one). My doctor said something like 10%-15% of diabetics end up having to move to something else because while it generally gets better for most after taking it a while, it doesn't for all. On the flipside, many take it and would never even guess that could be a side effect. Just luck of the draw.