On: Show HN: An open-source implementation of AlphaFol...

[EdHarris]

Folding@home uses Rosetta, a physics-based approach that is outperformed by deep learning methods such as AlphaFold2/3.

[flobosg → EdHarris]

Folding@home uses Rosetta only to generate initial conformations[1], but the actual simulation is based on Markov State Models. Note that there is another distributed computing project for Rosetta, Rosetta@home.

[1]: https://foldingathome.org/dig-deeper/#:~:text=employing%20Ro...