Yes, but then you have to use a lot more complex electronics and production tolerances, as now you'd need to either distribute voltage reference for intermediate level all over the board, which essentially makes it exactly same system as with negative voltage, but with the third wire becoming ground; the same concept but worse implementation, or make circuits able able to discriminate between two different levels, this will be both difficult in terms of implementing the circuit, and will also lead to enormous energy waste, as part of your transistors will have to be half open (jinda similar similar to ECL logic, but worse).
