Transmission has never been found when the number of copies of the HIV RNA are below 200 copies/mL--the quantity of virus matters.
For context, the typical ejaculation from someone untreated contains between 10,000 and 1,000,000 copies/mL. With treatment, the average is 1-10 copies/mL.
Besides HPTN 052, there have been three other studies--PARTNER, PARTNER 2, and DISCOVER, of real-world (condomless) usage in mixed serotype couples
For context, the typical ejaculation from someone untreated contains between 10,000 and 1,000,000 copies/mL. With treatment, the average is 1-10 copies/mL.
Besides HPTN 052, there have been three other studies--PARTNER, PARTNER 2, and DISCOVER, of real-world (condomless) usage in mixed serotype couples
https://www.idsociety.org/science-speaks-blog/2021/u--u-the-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8942556/