> It seemed to me that you were downplaying this person's experience
I'm not.
> were suggesting that they were possibly given other substances.
I am. There are a lot of people buying mislabeled products thinking they are ingesting chocolate made out of mushrooms that, in fact, are not. There are also people who sell other mushrooms, such as amanita muscaria, as your garden variety magic mushrooms. (I'm not aware of anything that would cause this with it, either, but it's got significantly less study and anecdotal reports.)
> I am saying that there really isn't a large enough body of scientific evidence yet to conclude definitively that there are no possible mechanisms that could cause this effect, as you stated. Humans aren't uniform systems.
You're putting words in my mouth. I never said anything about there being definitively no possible mechanisms. I said there are, to my knowledge, not known pharmacological mechanisms. If you want to dispute that, you're going to need to find some known pharmacological mechanism.
> HPPD comes to mind, serotonin syndrome, all sorts of possibilities that do not necessitate it being caused by another substance.
HPPD can cause a variety of visual phenomenon. That is not the same thing as having a 3 week long headache. SS is a possibility but now you're into multi-drug interactions, and I'd argue the blame is more on the MAOI or SSRI - those things interact with everything. But even still, the majority of SS cases subside in <24 hours... and the literature isn't exactly favorable to the idea that psilocybin is even a good candidate for causing SS in these cases. https://www.pharmacytimes.com/view/assessing-risk-for-seroto... (Thomas has done several meta-analysis on this subject so he's about as informed on this topic as you can be.)
When something doesn't fit the current model of something, you ask questions about it - that's the starting point to pretty much any investigation. I'm unsure why you find this so egregious.
I'm not.
> were suggesting that they were possibly given other substances.
I am. There are a lot of people buying mislabeled products thinking they are ingesting chocolate made out of mushrooms that, in fact, are not. There are also people who sell other mushrooms, such as amanita muscaria, as your garden variety magic mushrooms. (I'm not aware of anything that would cause this with it, either, but it's got significantly less study and anecdotal reports.)
> I am saying that there really isn't a large enough body of scientific evidence yet to conclude definitively that there are no possible mechanisms that could cause this effect, as you stated. Humans aren't uniform systems.
You're putting words in my mouth. I never said anything about there being definitively no possible mechanisms. I said there are, to my knowledge, not known pharmacological mechanisms. If you want to dispute that, you're going to need to find some known pharmacological mechanism.
> HPPD comes to mind, serotonin syndrome, all sorts of possibilities that do not necessitate it being caused by another substance.
HPPD can cause a variety of visual phenomenon. That is not the same thing as having a 3 week long headache. SS is a possibility but now you're into multi-drug interactions, and I'd argue the blame is more on the MAOI or SSRI - those things interact with everything. But even still, the majority of SS cases subside in <24 hours... and the literature isn't exactly favorable to the idea that psilocybin is even a good candidate for causing SS in these cases. https://www.pharmacytimes.com/view/assessing-risk-for-seroto... (Thomas has done several meta-analysis on this subject so he's about as informed on this topic as you can be.)
When something doesn't fit the current model of something, you ask questions about it - that's the starting point to pretty much any investigation. I'm unsure why you find this so egregious.