On: Psilocybin desynchronizes the human brain

[lawlessone]

>Healthy adults were tracked before, during and for 3 weeks after high-dose psilocybin (25 mg) and methylphenidate (40 mg), and brought back for an additional psilocybin dose 6–12 months later.

Not simultaneously I hope.. that sounds like it would be a rough ride

[brotchie → lawlessone]

"it can generally be assumed that there is approximately 15 mg (+/- 5 mg) of psilocybin per gram of dried mushroom" -Wikipedia

So 25mg is ~1.5g of dried mushrooms.

Decent dose, but not a "omg I'm one with the universe."

For instance, a "Hero Dose" typically starts at 5g of dried mushrooms, so ~3x the dosage used in the study.

Though it's possible the uptake rate using their dosing mechanism is much higher than "stomach acid digested dried mushrooms."

[newzisforsukas → brotchie]

> So 25mg is ~1.5g of dried mushrooms.

1.25g - 2.5g *

[collyw → newzisforsukas]

That isn't a high dose. Medium.

[mistrial9 → brotchie]

some kinds of mushrooms can grow tolerance fairly quickly, also.. based on info from a friend

[titanomachy → lawlessone]

"[methylphenidate] was selected as the active control condition to simulate the cardiovascular effects and physiological arousal (that is, controlling for dopaminergic effects) associated with psylocybin"

[jkingsman → lawlessone]

No, they were separate dosages to compare FC effects.