My disorder was caused by too much ATP in the mitochondria and too little in the cytosol. I have a Partial PNP Deficiency[1].
The higher ATP and GTP in my mitochondria causes higher sensitivity to all the G Protein Coupled Receptors[2], this includes the serotonin and dopamine receptors. So any increases in serotonin was exaggerated leading to psychosis and delusions much like someone would have on psilocybin.
This was cured by a low calorie, high seafood diet, a lot of walking, and limiting exposure to oxidative stressors like air pollution.
Most people however have the opposite problem; too little ATP in the mitochondria and too much in the cytosol. This leads to low energy receptor function. So when that person is exposed to dopamine there is very little reaction so they keep seeking dopamine. Hence we have depression and addiction.
In short, changes in the Purinergic pathway cause mood disorders. And this is not even a radical statement, it is just not well known[3].
So you can see why things like SSRIs will work, but stop working after a while. Since nothing is being done to correct the low mitochondrial ATP.
The higher ATP and GTP in my mitochondria causes higher sensitivity to all the G Protein Coupled Receptors[2], this includes the serotonin and dopamine receptors. So any increases in serotonin was exaggerated leading to psychosis and delusions much like someone would have on psilocybin.
This was cured by a low calorie, high seafood diet, a lot of walking, and limiting exposure to oxidative stressors like air pollution.
Most people however have the opposite problem; too little ATP in the mitochondria and too much in the cytosol. This leads to low energy receptor function. So when that person is exposed to dopamine there is very little reaction so they keep seeking dopamine. Hence we have depression and addiction.
In short, changes in the Purinergic pathway cause mood disorders. And this is not even a radical statement, it is just not well known[3].
So you can see why things like SSRIs will work, but stop working after a while. Since nothing is being done to correct the low mitochondrial ATP.
Comments so far?
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338719/ [2] https://www.guidetopharmacology.org/GRAC/ReceptorFamiliesFor... [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262688/