I mean permanently disable all speculative execution on a specific core and reduce/disable all side-channels of the kind. If you're saying I can do through injection of fence instructions between every instruction, coupled with isolcpus... I might have a fun weekend coming playing with Intel Pin. But I'm guessing the performance hit might be worse than 'just' disabling speculative execution on a core - if it was possible at all - or that the fence instructions might not be enough there? Haven't thought it through.
But it would be a fun question to ask the likes of Daniel Gruss...