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For Brilliant Color: Packaging the First LSD Blotter (mitpress.mit.edu)
226 points by anarbadalov 7 months ago | hide | past | favorite | 217 comments



Reminded me of this article:

https://www.vice.com/en/article/7b7kv4/mark-mccloud-collects...

Mark McCloud has about 30,000 tabs of LSD. He collects them, frames them, and catalogues them in his San Francisco home, which is why Mark gets periodically arrested by the DEA.


He's a fascinating character. Erik Davis (author of this piece) collaborated with McCloud's Institute of Illegal Images to produce his new book on Blotter tabs: https://mitpress.mit.edu/9780262048507/blotter/

(full disclosure: i work for the MIT Press)


> Should everyone take acid?

> No, because you have to ask the right question to take it. Do you want a one-on-one with your maker?


This right there is why pagans get a lot more fun out of it. ~


too bad images links are broken



> Mark McCloud has about 30,000 tabs of LSD.

Hopefully he won't take all of them like these guys: https://notsoprofound.com/the-unforeseen-lsd-overdose-of-197...


Indeed, no thanks!


He was also a psychedelic jazz musician - his Secret Sauce album from 1975 was rereleased recently:

https://ericghost.bandcamp.com/album/secret-sauce


This is fantastic, one of my favorite jazz forms. Thanks for sharing it!


Wow that's very nice


Sounds awesome!


Psychedelicatessen is an awesome name for a headshop. :-)


Agreed. Inspired by your comment, I did a Google map search, and there appear to be no places currently sporting that name, though there was a bagel shop in Troy NY with it, closed down in 2019.

So, you know, there is a vacuum waiting to be filled. Could be filled by a head shop, could be by anything…


> could be by anything…

A JS framework is probably nabbing it as we speak


These days, cool kids are into LLMs.

https://github.com/EGjoni/DRUGS


"Just call the dropTab() function and watch as your webpage transforms into a brilliant galaxy of colors and sounds!"


And it was a fantastic bagel shop, at that! The community was very sad when it closed doors.

You'd think there'd be many more with a great name like that.


It's funny to me that there are two cities in New York named Troy and Ithaca.


I have always enjoyed all the little towns named identically to other places. Maine, New York; London, Ontario; Mexico, Maine. There are a lot of others.

"Where are you from?" "We came from London." "Oh, all the way from the UK? You don't seem to have an accent at all!" "No, it's about 30 miles from here."


In Germany, we have cities with identical names, too (Frankfurt, Halle, most likely others I am unaware of). But being a much smaller country, it doesn't lead to much confusion.



Maine is full of them. There’s a China, Maine as well as Palermo, Belfast, Belgrade, Poland, Peru, Denmark, Dresden, South Korea, Stockholm,Calais…


Not all fun and games. My buddy lost his luggage for three weeks because the airline routed it to the "real" city.


There's an xkcd for that!

https://xkcd.com/2480/


Bagdad, Arizona;


Way back when I did an internship in Rome, NY. The "NY" part was very important to say to avoid confusion.


Ha. Yeah, there's PA weirdness, too. Once dated a girl from Mars. And of course you can't forget about Intercourse.


>> could be by anything…

Bongs and Bagels?

I think I know what my YC pitch is.... A side line delivering weed AND snacks


It also maps beautifully with many available TLDs:

https://i.imgur.com/pP1TjeI.png

Not sure which I like best, .love, .info, .net, .pro or .me :-)


That's pretty neat packaging, but it is unclear if the text about LSD would be visible from the outside. I imagine it would have to be completely invisible to be considered any sort of stealth. It's neat that the 5x20 design implies that it was rectangular, probably designed to mirror the size and shape of film. Each package shipped with 1,000,000 micrograms.

Finally, it's pretty incredible that something like this survived. Most people follow a "dispose of the evidence" protocol when it comes illicit drug packaging.


I think it was inside based on this excerpt: “Opening Ghost’s package, purchasers would discover a handy information sheet that today gives us a sense of how some underground purveyors understood and promoted their wares.”


> Each package shipped with 1,000,000 micrograms

Woah there buddy. 100 droplets at 1,000 μg each = 100,000 μg.

I was a little surprised to learn that they didn't just dilute it a bit more and soak the entire sheet.


And on that note, as a non-user, surprising that the standard tab is 1,000 μg and one is expected to just know that you should divide it into quarters just to get a mere "above average dose". Or into tenths or twentieths of a tab to get an average or below average dose, respectively. It seems to invite a white-knuckle ride.



If you soak the entire sheet, I don't think you can be certain how much active product a single blotter absorbed


But with the make-100-droplets technique, how can you be sure that each droplet contains the same amount? You're still relying on diffusion of solutes to achieve some degree of uniformity across several fixed volumes.


Diffusion in liquid is relatively consistent. When paper is soaked and allowed to dry, it can produce uneven concentrations as regions evaporate at different rates, and solutes move along with the flow of solvent. A good example of this is water color painting: if you mix paint into water and then apply it to the paper, the resulting patterns may be less uniform than when applied.


I see, thanks. I guess drying is essentially crystal regrowth, and the thing about growing crystals is that the material concentrates around the nucleation sites and spoils the nice even distribution that you get from being in solution.

Seems like one can expect a hit to be a more precise dose than a half-hit, presuming it's still done that way.


LSD doesn't show up on piss test.

It's somewhat unique in that.

Something to keep in mind.


People with light iris colours may not wish to rely on that.


Why?


Dilates your pupils to the size of dimes. Much more than the eye drops at the optometrist do.


The story I heard was that LSD is detectable in piss; but it's all been excreted in half an hour, before the trip comes on.


It shows up in blood tests for about 24 hours though, IIRC. But you'd have to be testing for LSD specifically.


More like it's just not tested for, I don't think a urine test exists for LSD.


It is active in extremely tiny doses. Micrograms. That's why.


Right but that may not preclude testing via auxiliary indicators. It could prompt other changes that you could test for, but, you're right, I'm assuming that's just not possible.


nah, I don't think there are reliable ways to detect it from urine / saliva, which is why they do it with blood tests instead


Wow, is this what the Paul Simon song called Kodachrome is actually about? (Please don't make fun of me if this was already a known thing.)


That's a great folkexplanation but the wikipedia page makes it sound unlikely:

https://en.wikipedia.org/wiki/Kodachrome_(song)#Development


That song is the first thing that went through my mind, too. It's an interesting re-framing of the song, even if there's nothing to it.

There's nothing in the Wikipedia entry that contradicts the possibility, though. Both could be true, with illicit details elided from the official telling.

Still I'm choosing to believe in innocent origins.


and Lucy in the Sky with Diamonds is unlikely too:

https://en.wikipedia.org/wiki/Lucy_in_the_Sky_with_Diamonds

you can't help wondering though...


you can't help wondering though...

That's true but at least we have a bit more to go on there (if not specifically about Lucy in the Sky) - I can't dig up the original reference but it's a famous enough story to paste from a random google search result:

John told Derek Taylor that when he and Paul dropped acid together they “just stared into each other’s eyes saying ‘I know, man’ and laughing”


Great article, makes me want to finally read the author’s Techgnosis book which has been on my shelf forever.


Erik Davis is awesome. I took a class taught by him in the early 2000s. It was inspiring.


TechGnosis took three tries, but in the end it was worth it IMO.


"cited as a cure for homosexuality"

Always a bit hurtful to be reminded of stuff like that.


If you ever get the chance of taking LSD on a good set and setting (don't even try otherwise) and your family has no history of mental ilness, go ahead and take it. It's gonna be one of the most interesting experiences in your life, to say the least. There's nothing like a psychedelic experience, I can't even put it to words.


Relative of mine got schizophrenia and bipolar disorder after taking psychedelics. No family history before then. Now he has to be continually drugged up and is a shell of his former self.

Unless you are trying to treat some other illness it isn’t worth the risk until we better understand the mechanisms behind why psychedelics can trigger mental disorders.


> Unless you are trying to treat some other illness it isn’t worth the risk until we better understand the mechanisms behind why psychedelics can trigger mental disorders.

Speak for yourself. Risk tolerance is highly subjective.

It's true that a small percentage of individuals who try psychedelics will develop otherwise unexplained mental illness. It's also true that a small percentage of individuals who try skydiving will break their legs and that a small percentage of individuals who try scuba diving will drown. However, ultimately, it's up to individuals to decide for themselves whether it's worth bearing such risks for the sake of experiencing something new and exciting.

Personally, I'd recommend that healthy people try all three of those activities. Life's short, after all, and you're more likely to get hurt in a car accident on your way there than you are to suffer injury from any of those particular activities in and of themselves. In every endeavor, it's up to you to do your own research and make as rational and informed a decision as you can given the available evidence.


Do you have statistics to back up the relative safety of those activities? Lots of people get in trouble with car accidents because lots of people drive cars. But I would think that if you both drive and skydive, the latter is far more likely to hurt you.


As with many complicated analyses, we can introduce hypothetical artifacts or simplifications to serve almost any hypothesis!

For example, most skydiving is done in a guided and controlled way, with participants paying a professional instructor to help them through the process on a flight where everyone involved knows that people will be jumping out of this plane, in areas chosen by said flights for this to be done in. The risk of injury or death would be much higher if you were to, say, bowl over a flight attendant on a commercial plane flying over, say, the Rocky Mountains, steal a backpack from a supply area that you assume is a parachute, shove open the emergency exit, and jump out. However, that risk might be significantly lower if you happened to have prior training as a military paratrooper

Lifetime risk of death in a car accident might come down to frequency. But it could also be affected by such factors as road conditions, weather, your own physical and mental health, the condition of your car, and whether you're being pursued by a military helicopter

Broad statistics tend to be a poor substitute for understanding one's own situation in assessing the risks one is willing to take. They are used in science because science tends to aim to draw broad conclusions over large aggregates. Your own individual risk assessment may take such aggregate measures into account, but it's unlikely that this is adequate to make such assessments wisely, and either way only informs your assessment of risk rather than your tolerance for it


I wouldn't necessarily recommend psychedelics to everyone, regardless of health. I'd love for it to be made a legal option though, for those that do want to try it of their own volition.


Legalization also opens crucial gateways to clinical research and market regulation. These effects can be better communicated and consumers have legal advocacy if they are harmed.


Absolutely. One of the big dangers of obtaining LSD right now isn't just the effects of LSD itself, it's the risk of getting something else like NBOMe that could flat-out kill you. A regulated market would allow the purchase of real, clean LSD, without the risk of more dangerous substitutes.

People have taken less than a few doses of NBOMe and died. Meanwhile there are no known deaths by LSD overdose, people have taken thousands of doses of LSD and lived.


There is speculation that an elephant suffered a seizure and died in 1962 after it was given a "god" dose which is kinda fun. The wiki page also suggests they tried to help it and accidentally killed it that way. Definitely something to consider if your friend Jake goes catatonic while staring at Yugioh cards and the EMTs misdiagnose.

https://en.m.wikipedia.org/wiki/Tusko


I think giving LSD to an elephant (especially 300mg, holy crap) is a very very bad idea, animals can't really be informed of its effects. You can tell a person what to expect and not to panic, but you can't do that with an animal. I wonder if that would be animal abuse also.


Oh for sure. The implication is that it would be nice to have the Healthcare infrastructure and research to safely industrialize psychedelia. Animals deserve better treatment in pharma dev anyways, but so does Jake who can consult a specialist psych if they want to. Similar to consulting a physician or experienced trainer before body building.


There is no proven causality between psychedelics and mental illnesses. We have so far only hypothesis.

But sure, you're doing something not well researched when you take psychedelics, and various people have very different experiences with them from getting a revelation to having the worst experiences of their lives.

So yeah, there are unknown risks and unknown benefits, thread carefully and take that into account.


AFAIK psychedelics cause the brain to become more interconnected for the duration of their effect, which can activate parts that aren't normally active. What we don't know is exactly what parts can just be activated in this way to trigger schizophrenia (or other disorders), and how to detect how much at risk someone may be.


While there is evidence to support some of what you're saying, the physical mechanism backing the causal relationship between psychedelic use and psychological disorders is far more complicated and nowhere near as well understood as you seem to believe. Heck, the physical mechanism behind nearly all psychological disorders in isolation remains poorly understood, let alone their interaction with any particular psychedelic.


> the physical mechanism behind nearly all psychological disorders in isolation remains poorly understood, let alone their interaction with any particular psychedelic.

That's what I'm saying, though. There's no way to know how susceptible one is to a particular disorder in general, let alone while on psychedelics.

There is evidence of psychedelic use connecting parts of the brain that aren't normally connected, AFAIK the white matter becomes much more interconnected during a psychedelic trip.


100% worth any risk.


I think most people with type-2 HPPD would disagree. (I had type-1 HPPD for a week or two and enjoyed it, but most people usually don't.)


I would bet most people who have used it would wish its use were more universal, say by politicians or corporate executives -- anyone with power.


I feel like LSD is way more visual (basically a fun rollercoaster ride) and the actual introspection happens on stuff like shrooms.

Obviously when you start taking high doses and reality kind of breaks down the distinction becomes moot, but at regular doses it does matter.


I like saying that it is an S4 - set, setting, substance, and soul.

And the substance (as long as it is a tryptamine) is less important, save for personal preferences. (I have heard a lot about LSD for fun and shrooms for insights - for me, there is no such distinction; if anything, LSD, even in lower doses, produces more profound associations, ones that words cannot capture. At higher doses, well, as you said, the distinction becomes mood.)

At the same time, the soul (overall personality, mind, motivations, desires, approach, will, and goals) is crucial.


> I feel like LSD is way more visual (basically a fun rollercoaster ride) and the actual introspection happens on stuff like shrooms.

Funny, I usually have the opposite experience :) LSD for deep, not-so-much visual, inwards journeys and mushrooms for very visual, laugh-y and social experiences.


Same... I was wondering if I was the only one. And DMT if you really want to question reality.


This could depend on neurotype.

When I'm on LSD, one of my favorite things to do is talk to friends over text. It results in me saying stuff that I could never say otherwise. Here is something Emily (a headmate of mine) once said:

> ....there must always be sadness... because all that is good will always end.... and it will never stop being sad that it is this way~

For me, thinking like that just does not happen without LSD, it was a complete accident but it's so pretty!


The visual aspect makes me wonder if the LSD experience in people with aphantasia is substantially different?

I'm 53 now and hope that before I die (which I hope isn't anytime soon) there's a safe and legal way for me to try LSD.


It's a lot more like... abstractions and associations become more malleable. This can inform perception even if you don't visualize, which can parse as visual distortions even in your "actual" vision, but might not. I think probably the biggest difference is going to be whether you experience "closed-eye visuals", which a lot of people report being pretty interesting on adequate doses of psychadelics, but they're far from the only interesting way in which that sort of altered state can manifest


> The visual aspect makes me wonder if the LSD experience in people with aphantasia is substantially different?

I'd love to tell you, but I don't know how people without aphantasia experience LSD. What I do know is that my inner experience is only (mostly) blind; it has fully developed senses of hearing, touch, smell and taste. I get visual distortions, apparently within normal parameters. Thus far in the few experiences I've had with synesthesia, it's never involved my sense of sight.


We phantage, but not to the extent as others.

That said, I must highly recommend not using in attempt to “fix” one’s aphantasia.

Edit: I recommend to stick to shrooms if you can.


Agreed. Shrooms were way more meaningful than any of my LSD trips, personally.


If it's their first time, a regular dose is certainly quite sufficient to trigger introspection if people are so minded.


I honestly don't wish its use were more universal. I wish it were available to me over the counter, so I wouldn't have to get it from the dark net and possibly get scammed, but I don't think it's a universally good thing. Not everyone would benefit from using LSD.


I think the specific type of mental illness to worry about is schizophrenia/psychosis. I have DID, but am autistic and have never been able to cause psychosis or anything like it, so LSD has turned out to be really safe for me so far. I have other friends who react much differently, so maybe it has something to do with neurotype.


It's gonna be one of the most interesting experiences in your life, to say the least.

I am always fascinated by this conundrum. A lot of people say it's a life-altering experience, yet it generally doesn't seem to make them a worse, better, or even different person (unless they have a mental illness ).


>yet it generally doesn't seem to make them a worse, better, or even different person

I think there's a vague consensus that one must 'integrate' the experiences you have on psychedelics in order to meaningfully impact your life, if that's your goal. Those profound experiences and feelings you can have on psychedelics are certainly incredible and moving in their own right, but in order to make that have an effect on who you are (increased empathy and better framing of life events are often mentioned), you the taker of those drugs has to put some work in to learn from it. It always bothers me when I'll see statements like 'this drug changed my life', especially when talking about psychedelics. The drug didn't do it alone.

This is also seen in the early work using MDMA by psychiatrists - the drug itself was just one part of the treatment.


> It always bothers me when I'll see statements like 'this drug changed my life', especially when talking about psychedelics. The drug didn't do it alone.

Yeah, I never liked that phrasing either. It makes psychedelics seem like some magical mental health panacea.

Often people who seek out these drugs are already taking the first steps to change their life (this can mean many things, even if "only"[1] changing their outlook) before ever taking the drug. They changed their life on their own, the drug was just a means to an end.

[1] I put only in quotes, because anyone who's struggled with any mental health issues knows this can be a gargantuan hurdle


> It always bothers me when I'll see statements like 'this drug changed my life', especially when talking about psychedelics. The drug didn't do it alone.

Are you always this precise when causality is being assigned though? Take geopolitical matters for example, when you hear a story about what caused some event on the geopolitical stage being attributed to one variable/entity do your spider senses perk up and realize you're being told a tall tale?


>> life-altering experience ... doesn't seem to make them a worse, better, or even different person

The best insight you will get, without taking the trip yourself is going to come from reading Huxley's "Doors of Perception". A large enough dose will give you all sorts of interesting insights into your own thinking.

The closest your going to come to this, is the first time you watch the film "The Game", assuming you pay close enough attention and are tuned into it as a film and the characters in it. However it pales in comparison to the real thing.


Culture is a more powerful drug but it is spread out over vast periods of time so we don't notice it. It also defines reality, which is more than a little helpful during disagreements.


Agreed. It's annoyingly hard to come across though for me, and for most people I'd imagine.


Go to the nearest jam band show/festival near you, you'll find some in under 5 minutes


Just hang around in the lot, it will find it's way to you.


A friend of mine noticed his hair had reached a certain length when people stopped trying to sell to him and started trying to buy from him.


For decades now, whenever I've tried to make a street deal, the vendor has sidled away, saying "I think you're a cop". I don't have much hair nowadays.


Our friend group occasionally dropped acid in high school.

There were a couple kids we didn't know well that went schizophrenic/psychotic break.

My closest friend got too much in his early twenties at an early burning man, went schizophrenic/psychotic and after a year or so in and out of jail, committed suicide by cop. There was nothing that could be done for him as he was an adult and didn't want help.

This was a college educated, elementary school teacher.

I haven't touched the stuff since.

You do you, but don't tell people there aren't risks.


They didn't? But thanks for putting words in people's mouths


There are definitely people here talking about LSD with statements like, "100% worth any risk" and others talking about it as if there are no risks.

I used to share this attitude, but seeing a close friend have a complete break and lose his life over some recreational partying changed my view.


I loved acid as a late-teen. I took a lot. I didn't take the view that it should be legalized; I was OK with it, but it wasn't hard to imagine someone getting seriously screwed-up by it. Two of my friends were hospitalized for psychiatric disorders after taking it, but I suspect they were both latent schizophrenics.

So I'd talk about it enthusistically (like any acid-head!), but I'd never recommend itto anyone.


That's the kind of informed take I was looking for. Thanks.


Reminder. Psychedelics can also lead to extremely traumatic experiences:

https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=23788

This doesn’t get mentioned in the current “psychedelics as a cure-all” hype wave.


Aren't people always talking about set and setting, after-trip integration, not taking them if there is a history of mental illness, not being on SSRIs, etc? If anyone at any time is telling people that something doesn't come with some sort of risk, they're either lying or ignorant. Especially true when it comes with the mind.

Also, reading this linked person's comment, they were on DMT and it sounds like they have some strong ideas about how the universe works (they mention having been to "heaven" before and keep mentioning hell and evil and devils as if they are real). Yes, people should be careful, especially when they have issues with mental health.


DMT is related to LSD (they're both tryptamines). I think DMT made them hallucinate those things which is why they talk "as if they are real" - that's something they felt like they genuinely experienced, which is what made it so traumatic.

As for the heaven thing, I do not know if they were particularly susceptible to delusions before ever taking anything, but if they were, then it was probably not the right choice, yeah.

It's hard to be self-aware about delusions if you don't know they're delusions. It's definitely possible though: https://www.youtube.com/watch?v=GU8VmJsX6-s


Oh for sure, I'm well aware of what DMT is like and I know it's very easy to get confused by things that come up during those trips since they are so vivid, which is why integration is important. He also took 60mg, which is on the high end of a strong dose afaik.

I've wondered if it would be useful to approach psychedelics similar to the way that meditation is taught in vajrayana lineages, where you have to do preliminary mind trainings before you start advancing to other practices. If you encounter "hell" in a bad trip, like the person in the post, but have no way to understand it, it's easy to believe in it literally.

I just watched a few minutes of that video you linked and I'll definitely watch it later, he seems very lucid about his delusions, thanks!


That's not been my experience, warnings about set and setting and being in the right headspace are pretty typical. It might not be mentioned in popsci articles but they're not expecting you to go out and actually take any.


The second time I took LSD, I had visions of rending flesh, falling endlessly into a vortex of gore. That was the mandala that time. This was mixed with dreamscape fantasies of conquest and rape on grandiose scale, a Roman emperor, slicing down hordes, restructuring time in a slash of blood, a ball of divine destruction held in potential, ready to be unleashed at any time. It was sexually arousing.

Some might rationalize this, as getting a better grip on one's Jungian shadow. I sometimes view the experience that way, but sometimes I wonder if it slightly loosened some important retaining bolt. I'm pretty sure negative vibes can come out of the Pandora's psychedelic box, too. Also, this variability in effect hinders using it therapeutically. It's hard to "guide" a trip, and no one really trips in the same way twice.


That's interesting (that you felt the disturbing images as arousing). I work at an ayahuasca center that works in a traditional lineage. One thing that often needs to be energetically cleaned from people is something we refer to as "lobo" ("wolf" in Spanish), or neino (Shipibo for river otter), both considered to be somewhat voracious animals. This is the spirit of unhealthy desires, often sexual in nature. It manifests in a variety of ways, often images of sea creatures. When it is most intense it appears as very bloody and gratuitous violence, bloody animal teeth etc.


Was that a heroic dose? I've had some strong visuals, but I've never been blasted into full blown hallucinations on LSD.


Not op, but I've done heroic doses a few times (and lesser ones too).

You don't need a heroic dose for ego death (but it probably helps). You could be listening to music in a dark room or with closed eyes, on a medium-high dose and you suddenly start disassociating.

Also, you don't normally hallucinate in the same way media portrays it (there are drugs that make you hallucinate though) AFAIK (none of my friends or I hallucinated on psilocybin/LSD; I wouldn't call DMT hallucinations either). Ego death trips are more conceptual than purely visual, but there's a strong visual aspect to it too.


I had had 15-20 ‘normal’ trips and then one (probs around 250mcg, but during Covid when I was totally spent and my ‘intention’ was to let go and wash away the stresses) where I was just ‘not there’. I had some pretty intense/scary visuals/thoughts, but what was terrifying to my partner and friend there was I was bumping into walls and just muttering. I had a new respect for why they call it chemically induced schizophrenia, I was just not home for 2 hours. Afterwards it wasn’t the worst thing in the world, but I had a massive newfound respect and have been very cautious with tbe dose (and intention!) the few times subsequently


Are heroic doses supposed to do something special? LSD always feels the same to me, whether it's 100ug or 500ug. Higher doses just last longer, but aren't any more intense.


If you're taking 500ug and it just seems longer, I would question if you're actually taking acid or the dosage. That's like 5ish+ hits my dude. Yes, it should be much more intense (and longer). However, you do need to take it all at once. If you wait a couple hours and re-dose, it does just make it last longer.


I'm certain it's LSD25 because if it were anything else (like NBOMe) I would have died by overdose by now. I'm aware the typical dose is 100μg. I've taken up to 600μg before (yes all at once), and it'll keep me wide awake for 24 hours straight but the actual trip itself won't be that much more intense.

I'm autistic and have ADHD so it might affect me differently than the typical person. I don't necessarily like it that way (I would love one of the super-intense experiences that people tend to get really excited over) but so far I haven't been able to cause a particularly strong effect. Very curious why I'm either more resistant to it or more tolerant of it to the point of being underwhelmed.

Don't get me wrong, it's still a very nice experience that I like to partake in every couple weeks. The first time I did LSD (100μg) I got HPPD for about a week, sometimes I wish it never went away. Being sober is so boring!


If you're getting it from the same source, you might want to test it. That doesn't sound right. It should be metabolized well before 24 hours. 6 hits of acid shouldn't last that long, and I'm not sure any dose can.


Two different sources, exact same effect.


I cannot upvote this enough. Having a bad trip is plainly one of the most horrible experiences of my life


I agree with this but I found it to be an extremely valuable experience all the same.


Like driving a car or taking a flight can lead to death. Sure, what are the chances?


Could be very large, even close to 1, depending on how you react to it


Sure? It could be bad for you if it’s bad for you, but the factors and reactions are pretty varied. Taking psychedelics is kind of like driving up a mountain - if it’s storming (anxiety etc.) and/or your lights are out (preconceptions, psychosis), you’re more likely to end up in a bad state, but there’s still the chance of making it to a scenic view, and the people who do get a pretty significant (learning) experience out of it.


In general, LSD is something that I wouldn't recommend to just anyone because the outcome of a trip depends on your mental strength. You can definitely rewire your brain, which can be a good or bad thing depending.

There are plenty of tips online, but two that have stuck with me are:

* remember that it will end

* have something with you that you've had for a long time, because it'll be an anchor.

Neither of those thoughts/things may matter until they do.


The Reed College (IIRC) student handbook had some good advice, including something along the lines of:

* remember that you will be extremely tempted to answer complex questions like What Is Love? and Who Is God?

* when you are actually unable to answer simple questions like What Is Toothpaste? and Where Is My Left Foot?


Man, I wish I could find something that made me unable to answer those questions. That sounds fun. I dissociate a lot even without drugs, but have never quite gotten that far.


> remember that it will end

> have something with you that you've had for a long time, because it'll be an anchor.

* Have some Librium or Valium to hand.


> Opening Ghost’s package, purchasers would discover a handy information sheet that today gives us a sense of how some underground purveyors understood and promoted their wares. Rather than hippie mysticism or revolutionary cant, Ghost’s text presents LSD as a scientific product of a modern research lab run by a pharmaceutical corporation.

Without more information, that conclusion seems to be going too far.

The package is a parody of a commercial product, and it would be totally unsurprising to me that the parody extended to the attitude of the text. Kodak almost certainly presented its contemporary film as "a scientific product of a modern research lab" in a similar way.



Oh, I know. I'm just saying that fact doesn't have any particular bearing on "how some underground purveyors understood and promoted their wares," and you cannot really unpack the non-parody aspects of a parody with only access to the parody itself.


> It has been cited as a specific cure for frigidity, impotence and homosexuality

Startup concept: a conversion camp where you take religious peoples' money and host LSD retreats for queer kids


Might have the reverse effect, I'd consider psychedelics (LSD specifically) one of the reason I no longer suffer from homophobia.


So you're saying that at the end of camp, we should require the parents to partake in a final session?


Although I know you're joking about the scenario, I fear that non-therapeutic psychedelic experiences have equal or more likelihood to compound bigoted predisposition or - given intense societal pressure - trigger repression mechanisms when confronted with honest reality.


My immediate concern would be acid-tripping parents calling the police to report that we'd groomed their children and roofied the adults. But, sure, if I survived the local goon squad raid, I might also regret your thing


You might be aware already, but your post reminds me of an old running gag on forums that "LSD turning homies into homos" because of a rumor LSD can make people gay.

Aside: I'm sure psychedelics helped many people come to terms with their speciality, or the altered headspace helped them come out to friends


Would you feel comfortable briefly sharing your experience?

I'm curious if you had an 'aha!' moment or maybe your environment at that time had any effects.


The "aha" moment was mostly about accepting that people are different and as long as they don't force anything upon me or doing anything affecting me, I shouldn't really care that much.

The environment was just my own apartment and a friend talking about various topics for ~10 hours when we were about 17 years old or so after a 1.5 dosage LSD (don't remember the exact dosage, but we had three sugar cubes with one dose each, one of them got split in half to share).

I grew up in a country-side place where homophobia and nationalism is basically thought by parents by default to kids. Doing "sieg heil" in a sneaky way during events was considered funny by most. Most of the people hadn't seen a non-white person until we had to start traveling to the nearby city for school, which happens around the 17 year old mark. So basically being exposed to lots of preconceived hate since birth.

A lot of the subjects we talked about were about acceptance as we both had our own experiences rejecting or distancing ourselves from people based on perceived "weaknesses", something we both realized was just introducing harm and isolation.


It's tough. Thanks for sharing.


I know you're only joking, but I wish a "haven" like that existed when I was a closeted, confused queer highschooler!

If someone wants to make this a thing (and it's legally viable), where do I send my CV?!


Well, let me stop you right there. What I described is outright fraud (and, yes, a joke). That's illegal approximately everywhere, not even considering the whole part where I suggested giving schedule 1 drugs to minors. If you want to pursue business in this sector, be sure that you don't associate your real name with this comment thread.


I was also joking about the business endeavour. Sorry I didn't make it more obvious lol


Poe's law strikes again!


Never forget the articles about the impact of LSD on early Cisco/Networking...

See previous thread here:

https://news.ycombinator.com/item?id=38970587

(and the menlo park studies... LSD is intrinsically linked to the development of silicon valley)


Thanks for that!

Super interesting!


Funny to see so much admiration for psychedelics from universities such as MIT.

Has there ever been any objective -strong emphasis- of the efficiency of LSD to improve cognition, creativity or consciousness? Because I definitely never see LSD listed in the category of "doping" substances. The main advocates are users themselves who think they had a revelation - but how much of it is self-delusion? I'd hasard it's a lot - if not all there is to it.

(I would be fun to imagine a plant of fungus whose evolutionary niche would be to seduce animals/humans they need it - leading to it being cultivated)


fun to imagine a plant of fungus whose evolutionary niche would be to seduce animals/humans they need it

There are numerous ongoing studies into the effects of psilocybin on terminally ill patients, the idea being that the psychedelic effects helps people face death calmly. Every time I think about that, I'm always tickled by the idea that perhaps these fungi have evolved a way to farm their own food.

https://ncbi.nlm.nih.gov/pmc/articles/PMC10106897/

Edit: Michael Pollan's book has a Netflix adaptation that addresses palliative mushroom therapy, among other uses: https://www.netflix.com/title/80229847


A friend of mine had a conversation with "Mr Mushroom" (while wandering a field one drizzly evening, tripping).

Sir Mushroom offered that he's a wizard from a thousand universes away. He travels everywhere, guiding people by the hand, introducing them to the larger world.


> perhaps these fungi have evolved a way to farm their own food

Aren't H sapiens just God's way of taking billions of prokaryotes on a trip to the moon?


I think the right way to think of it is as an _experience_. It doesn't make you smarter or more creative, any more than going on a backpacking trip or reading a good book -- it just gives you a new way of seeing the world and your place in it temporarily. What you do with that experience is going to be highly personal.

I know that people can become out-right messianic after an LSD trip, but people can be similarly evangelical about travel or books or, obviously, religious experiences.

later edit: I actually do think it's more to it than that, for two reasons -- one is that while you're on acid, your brain tends to make wild connections between things that you wouldn't ordinarily do, but I don't think that's good or bad, necessarily -- it's like running an LLM on a very high temperature, it can be funny and interesting, but it's very hit and miss. The second is that I think it triggers a lot of self-reflection (to say the least) and can help you recognize and break out of negative personal patterns -- but that also tends to be what people think of as "bad trips".


I would add that it's not necessarily just self-reflection, but also reflection on other people around you, and on the world in general. This kind of stuff can also go places that, while more accurate than one's original perception, are not necessarily what one might like. And unlike negative personal patterns, this might not be something you can do anything about (the world stuff in particular). I still consider that valuable experience in its own right, but then I was never a proponent of "the less you know, the more soundly you sleep". Others may have a different subjective preference on that.

As far as "messianic" stuff, I think it comes mostly from heightened empathy, which appears to be a fairly universal thing during a trip (even if it doesn't necessarily stick after).


Thanks. That sounds far more balanced than what one can find in psychedelic literature _à la_ Leary.


> it's like running an LLM on a very high temperature

I can second this, specifically. For me, LSD often triggers thoughts that can't be put into words - upon trying, out come sentences like this:

"can have a haves and take a three sixteenth quarters. can have a what's very much like. can have an um somethings or others .... mmm much of somethings or others.... can havings a taken umpteenth very good time ...."

Those are real sentences I typed up while on LSD, knowing that they were complete gibberish, but it's what came out of my brain when I tried to put the thoughts into words. The thoughts had some sort of meaning, but not in words, just indescribable concepts. Whatever part of my brain translates thoughts and concepts into words had never been trained on those types of thoughts before, so it came out as gibberish.


LSD was recently granted "breakthrough-therapy status" by the FDA after clinical trials show a single dose provides "immediate and lasting relief" from generalized anxiety [0]. I know you're asking about a slightly different effect, but IMHO they are related. I myself have experienced personal revelations through psychedelics that have had lasting effects and positive consequences in my life.

My gut feeling is that any revelations or breakthroughs people have from psychedelics could also eventually occur through other means (therapy, meditation, etc.), but not as quick. It's like a shortcut to the sort of deep introspection needed to unwind the stories we have ingrained into ourselves.

[0]: https://www.cnn.com/2024/03/07/health/lsd-anxiety-fda-breakt...


There's good evidence that psychedelics can increase neuroplasticity, you can web search those keywords. It would be surprising if it didn't at least sometimes help with cognition. On the other hand, a colleague who works in the field said to me "who says plasticity is good?" I've yet to ask him to clarify this; it challenges my assumptions but he is way more knowledgeable than I. There are also studies into psychedelics and creativity (as in problem solving, rather than painting) which again you could look up. The one I'm thinking of in particular was before the war on drugs and rather flawed methodology. But there have been more recent studies.


I am really interested in what your friend meant by "who says plasticity is good?". Plasticity seems to me to be seen as a quality in psychology, no ifs no buts.


Some interesting points raised by other comments to this post. My best guess is that he meant that you could have a traumatic experience afterwards that leaves you worse than before. Maybe (just spitballing) whatever mental defences you have against trauma are enhanced by not being too plastic.


There is no guarantee that when you break down and reform something, the end result is in any way “better”. This is especially true for reality.


that's the thing about resetting to default settings... sometimes your custom preferences were useful and they'll some time to reconfigure


"He who breaks a thing to find out what it is has left the path of wisdom." — Gandalf speaking to Saruman


> "Who says plasticity is good"

In Machine Learning, we might think of this idea as "setting your Learning Rate too high"


In ML, this will bump you into a nearby optima at random. That optima may or may not be better than your prior. And if it’s worse, there’s a good chance it’ll be very difficult to get back to where you were without external checkpoints to revert to.

The brain is the same, but no checkpoints.


I wouldn't say the brain has no checkpoints. Certain events (like concussions or stroke) can knock out memories or habits and result in roughly what was some months or years ago. Also, certain things like Dissociative Identity Disorder can result in past/younger versions of yourself splitting off and halting development for years or more. Then they can come back up later.

With that said, I don't think anyone really has control over this. I'm a DID system and I have some sort of limited control but my time skips are usually on the order of days or weeks, not years.


Research around substances like LSD, psilocybin, mescaline, DMT, and so many others have been absolutely hampered by the War on Drugs the USA started. Hard to get objective results from something that couldn't be studied without putting researchers' careers to death.


Doping substances are also regulated. And yet amphetamine use is everywhere competitive pressure is.

Also, I don't see any military adding LSD in the toolkit of military leaders. It has been tested as a disabling agent. But never found use as an enabling one, neither in the US nor in one of its enemies.


LSD (and other psychedelics) foster empathy, no military needs that in their fighting force, it's counter-productive for their goals...


I do t see it in widespread use in (peace) negotiations either, nor by therapists themselves - or any line of work where heightened empathy would be beneficial, such as acting.


Maybe peace negotiators are actually just actors. That would explain much of the hilariously transparent BS stories coming out of the mouths of various politicians, that everyone can sometimes realize and acknowledge as such, but other times not.


Ah, yes, the argument which ignores the fact that medical research also happens everywhere else in the world. If there was any medical value to any of this nonsense it’d already be well known in Europe, China, Russia, or India.


The Single Convention on Narcotics [0] (heavily influenced by US's policies) and the later Convention on Psychotropic Substances [1] extended the same bullshit to all signatories, so no, no other countries could research either.

I'd advise learning some history before berating me with bullshit.

[0] https://en.wikipedia.org/wiki/Single_Convention_on_Narcotic_...

[1] https://en.wikipedia.org/wiki/Convention_on_Psychotropic_Sub...

Edit: the repercussions of these conventions extend to this day even when countries attempt to legalise just cannabis, like Germany's case when moving forward with their legalisation which infringes on EU law against illicit drug trafficking [2], procedure 2001/0114/CNS is a direct side-effect of the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances [3] started... By US's policies against drugs in the 60s-70s. It's a direct link creating issues to this day by puritan American values.

Decades of potential research worldwide blocked because a politician in the US needed to get a weapon against minorities, fun, huh?

[2] https://eur-lex.europa.eu/legal-content/en/ALL/?uri=celex%3A...

[3] https://en.wikipedia.org/wiki/United_Nations_Convention_Agai...


Counterpoint: the Netherlands.


The Netherlands has not legalised anything, cannabis is tolerated but under its laws it's illegal.


This argument ignores the fact that medical research into the potential benefits of "this nonsense" has been under way in the US for over 20 years. Johns Hopkins has a dedicated research group in this area [1], and has published peer-reviewed research for various applications of these drugs.

It's easy to become cynical about psychedelics, because there's a ton of bullshit in the space. (And it's probably fair to assess that the push of these substances into the black market helped create an environment where only "hippie-esque" bullshit could thrive). But the results seem pretty clear that there's real potential in these drugs to alleviate human suffering in many ways.

Does that mean that these drugs unlock magical insights or enhance the intelligence of their users? Of course not, and no one serious is suggesting that they do. But there's been plenty of real research over the past two decades that makes dismissing the medical value of psychedelics as "nonsense" a fairly silly take.

[1]: https://hopkinspsychedelic.org/


> Does that mean that these drugs unlock magical insights or enhance the intelligence of their users? Of course not, and no one serious is suggesting that they do.

It's weird how people can make implicit claims of omniscience while on regular consciousness and nobody bats an eye, but far less ambitious claims on LSD are crazy talk.

It seems to me that regular consciousness epistemically privileges regular consciousness.


> t's easy to become cynical about psychedelics, because there's a ton of bullshit in the space.

And the bullshit stems exactly from it being a potential career death if someone attempted to research them in depth. Without factual and objective analysis the only knowledge left is a hodgepodge of anecdotes, except for the odd Alexander Shulgin or others more scientifically rigorous minded the reports came from users who are not a good cohort of people to objectively analyse their experiences.

MAPS [0] is one of the few groups who against the odds continued to research it, lately they have been advancing research on using MDMA for PTSD, psylocibin, etc. If it wasn't a huge taboo for decades for serious researches to enter the field this type of research would be much more advanced today.

[0] https://en.wikipedia.org/wiki/Multidisciplinary_Association_...


I totally agree, in case that wasn't clear. I was just responding to the notion in the parent comment that the whole field is nonsense, and that if it weren't nonsense, research would have come out of other countries.

(That notion seems suspect on its face, since those other countries have similarly strict drug laws, but that's not really my point - my point is that there's plenty of research in the field as of 2024, and it's not fair or accurate to dismiss it as nonsense).


twenty years of research at a respected institution and still nothing other than hippy fairy tales? sounds about right, thanks for the update.


I don't think there's any reading of my comment (or the extensive modern literature around this subject) where that's a reasonable takeaway.


Different aspects of cognition may be measurable to a useful extent, but the rest isn't that straightforward. Philosophers still argue about what consciousness even is at the most fundamental level, so quantifying that is not happening. Creativity is just as much about the volatile and fickle relationships among context, inspiration, stimuli, motivation, experience, emotional state at a very granular (likely imperceptible) level, etc. as it is about somewhat measurable things like abstract reasoning. You'd have to be able to look in two different dimensions– one where someone generated creative output having used a psychedelic and one generating the same creative output not having used it to see anything close to an accurate split, and even then, creativity is so subjective that it wouldn't prove much. Like many psychoactive substances, there are probably complex context-dependent trade-offs for the cognition, and when it comes to creative utility, they probably don't affect the process like someone would expect. Perception is relative; some senses may appear heightened (e.g. sense of taste with marijuana use,) when in reality, other competing stimuli are slightly muted. While that would be very consequential in quantitative cognitive measurements, the distinction is probably irrelevant in creative processes. If we didn't have an accurate way to measure sleep, someone would probably declare white noise machines bunk because noise interrupts sleep and they actually make your environment noisier.

Of course, through engineering, generative AI will surely save us from this burden of terribly ambiguous and inconvenient humanity by amalgamating existing humanity and extrapolating/interpolating based on a handful of plain text, so that's... great?


Creativity is difficult to measure in the lab, but if taking LSD was a game changer, you'd see a majority of creative workers taking LSD the same way Adderall & co are massively used (there and elsewhere - anywhere where staying more time awake and alert allows you to pull ahead).

Yet I don't see it: most LSD usage works the same way as absinthe or opium used to be used: as a crutch for creatives suffering a dry spell, with the user feeling improvement - but the public, critics, "consumers" of the creative product not really seeing it.

(Usually the crutch becomes an addiction, or the toxicity/impurities in the product take their toll, and you end up with a coda like at the end of PK Dick's _A Scanner Darkly_)

What I find most specific to LSD though is that it seems to have produced a long list of LSD advocates, whose work consists only of waxing poetics about how "LSD gives you mental superpowers", and... Not much else. No actual "general" poetry, no Great Text, no theoretical breakthrough in philosophy nor science...)


> but if taking LSD was a game changer, you'd see a majority of creative workers taking LSD the same way Adderall & co are massively used (there and elsewhere - anywhere where staying more time awake and alert allows you to pull ahead).

Does the same logic apply to eating healthy and exercising?


> Creativity is difficult to measure in the lab, but if taking LSD was a game changer, you'd see a majority of creative workers taking LSD the same way Adderall & co are massively used (there and elsewhere - anywhere where staying more time awake and alert allows you to pull ahead).

Firstly, showing up to work on acid is very different than showing up to work on Adderall. The impact on someone's ability to function normally is incomparable. Secondly, working faster to solve problems is not even close to doing things like honing someone's artistic perception in their medium, and having the mental material to manifest abstract concepts. Many of the benefits people reap from hallucinogens are experiential and could influence someone decades later, like travel or something they read.

> Yet I don't see it: most LSD usage works the same way as absinthe or opium used to be used: as a crutch for creatives suffering a dry spell, with the user feeling improvement - but the public, critics, "consumers" of the creative product not really seeing it.

I am a professional art-school trained artist who almost certainly knows many more successful artists than you do: you're either making things up to justify your existing opinion, or you don't know enough about the topic to realize you're making things up. The preponderance of dedicated professional artists and designers I know (on the artier end of the spectrum) have at least dabbled in hallucinogens. Personally, I have not. If you include marijuana, even though that's far more like Adderall in its usage patterns, that number is nearly 100%. Almost none of that drug usage, from what I've seen, is used in direct response to needing inspiration. Of course, none of this is universal, but to say it's not common or influential because you are not aware of many people that are working while tripping is utterly ridiculous.

> (Usually the crutch becomes an addiction, or the toxicity/impurities in the product take their toll, and you end up with a coda like at the end of PK Dick's _A Scanner Darkly_)

Ah-- that you're basing at least some of your conclusions on fiction certainly fills in some holes.

> What I find most specific to LSD though is that it seems to have produced a long list of LSD advocates, whose work consists only of waxing poetics about how "LSD gives you mental superpowers", and... Not much else. No actual "general" poetry, no Great Text, no theoretical breakthrough in philosophy nor science...)

You can find bullshit artists peddling damned near anything for their own benefit, and hallucinogens are one of the worst offenders. That's not an argument against the efficacy of anything. And to be clear, I'm not advocating for anything. Neither for hallucinogen usage, nor abstinence.


Thanks for your insights.

The fact that almost none of the drugs in the artistic milieu are used to get inspiration is interesting - you'd think those, especially LSD, would have been prime candidates, given their "legendary" reputation in Leary's advocacy work.

And just for the record: >Ah-- that you're basing at least some of your conclusions on fiction certainly fills in some holes.

"A Scanner Darkly"'s coda is not fiction. Here it is:

"This has been a novel about some people who were punished entirely too much for what they did. They wanted to have a good time, but they were like children playing in the street; they could see one after another of them being killed—run over, maimed, destroyed—but they continued to play anyhow. We really all were very happy for a while, sitting around not toiling but just bullshitting and playing, but it was for such a terrible brief time, and then the punishment was beyond belief: even when we could see it, we could not believe it…. For a while I myself was one of these children playing in the street; I was, like the rest of them, trying to play instead of being grown up, and I was punished. I am on the list below, which is a list of those to whom this novel is dedicated, and what became of each.

Drug misuse is not a disease, it is a decision, like the decision to step out in front of a moving car. You would call that not a disease but an error in judgment. When a bunch of people begin to do it, it is a social error, a life-style. In this particular life-style the motto is “Be happy now because tomorrow you are dying.” But the dying begins almost at once, and the happiness is a memory. It is, then, only a speeding up, an intensifying, of the ordinary human existence. It is not different from your life-style, it is only faster. It all takes place in days or weeks or months instead of years. “Take the cash and let the credit go,” as Villon said in 1460. But that is a mistake if the cash is a penny and the credit a whole lifetime.

There is no moral in this novel; it is not bourgeois; it does not say they were wrong to play when they should have toiled; it just tells what the consequences were. In Greek drama they were beginning, as a society, to discover science, which means causal law. Here in this novel there is Nemesis: not fate, because any one of us could have chosen to stop playing in the street, but, as I narrate from the deepest part of my life and heart, a dreadful Nemesis for those who kept on playing. So, though, was our entire nation at this time. This novel is about more people than I knew personally. Some we all read about in the newspapers. It was, this sitting around with our buddies and bullshitting while making tape-recordings, the bad decision of the decade, the sixties, both in and out of the establishment. And nature cracked down on us. We were forced to stop by things dreadful.

If there was any ‘sin’, it was that these people wanted to keep on having a good time forever, and were punished for that, but, as I say, I feel that, if so, the punishment was far too great, and I prefer to think of it only in a Greek or morally neutral way, as mere science, as deterministic impartial cause-and-effect. I loved them all. Here is the list, to whom I dedicate my love:

To Gaylene deceased

To Ray deceased

To Francy permanent psychosis

To Kathy permanent brain damage

To Jim deceased

To Val massive permanent brain damage

To Nancy permanent psychosis

To Joanne permanent brain damage

To Maren deceased

To Nick deceased

To Terry deceased

To Dennis deceased

To Phil permanent pancreatic damage

To Sue permanent vascular damage

To Jerri permanent psychosis and vascular damage

…and so forth.

In Memoriam. These were comrades whom I had; there are no better. They remain in my mind, and the enemy will never be forgiven. The ‘enemy’ was their mistake in playing. Let them all play again, in some other way, and let them be happy."


> The fact that almost none of the drugs in the artistic milieu are used to get inspiration is interesting - you'd think those, especially LSD, would have been prime candidates, given their "legendary" reputation in Leary's advocacy work.

It's not that they don't contribute to inspiration for some, or that some don't deliberately take them, at some point at least, to expand their artistic perspective: they just aren't useful as a work aid to mitigate a lack of inspiration like drinking coffee to mitigate tiredness. Hallucinogens are a leisure drug, not a work aid, and like many other kinds of intense leisure experiences, they can have significant impact on someone's work. Surely people make art while taking acid but it's just not used like you imagine it is.

>And just for the record:

>> Ah-- that you're basing at least some of your conclusions on fiction certainly fills in some holes.

> "A Scanner Darkly"'s coda is not fiction. Here it is:

It was a novel and he was trying to sell books. If you want to know what drug addiction is really like, start with some reputable, published, entirely non-fiction literature written to educate people, not entertain them.

I have not struggled with drug addiction, though being involved in several subcultures in my younger years, many people in my life have, and my list probably rivals his. In my adult life, maybe ten people ranging from fairly close friends, to family, and even an ex long-term live-in girlfriend have died from their heroin (which mostly started with something they were prescribed for pain,) alcohol, and in one case of meth usage. Many more permanently damaged. Their actual stories don't make snappy book codas: they're emotionally exhausting because the sadness of their existence is mundane, boring, and oppressive. Even my best friend in elementary school who after not seeing him for quite some time, I found out was shot by police soon after getting out of jail for robbing a pharmacy to get Oxycontin, seemingly, had an incredibly boring life. He lived with his mother in his late 30s, worked as a grocery store bagger, and didn't really go anywhere besides work, the liquor store, and home, (which is where he was killed.) Also, having worked in nightclubs for many years, I knew many people addicted to cocaine, but I don't know anyone that's died from it or gone to rehab for it (though some for their more severe alcohol abuse... they're very commonly used together.)

Those people that died of alcohol and heroin usage had some similarities in usage patterns. You know what that has to do with artists use of hallucinogens? Absolutely. Fucking. Nothing. Not one single thing. LSD not chemically addictive and it's nearly impossible to fatally overdose on. You will never find it listed in an article about "diseases of despair." People interface with it completely differently than heroin users, drinkers, marijuana users, and coke heads interface with their substances of choice. Consistently drinking coffee in the morning has closer usage patterns to the opioid people than hallucinogen users. Even with all of the artists I've known, only two of those dead people were artists: one was a drummer in a metal band I was briefly in, and another friend picked up painting in an art therapy program in rehab before that one last fateful relapse.

I get it, we all want to feel confident in our understanding of important topics. Being well-read is a good thing, but I think someone you trust needs to give you some version of the Good Will Hunting "You're just a kid" speech. You need to understand the limits of your knowledge. You are trying to pontificate about things you've read about in novels that were written decades ago about drugs that couldn't possibly be less relevant to the ones discussed here. Trying to reason about artists that sometimes use hallucinogens based on the experience of an artist who-- like millions of non-artists-- was addicted to heroin, betrays foundational gaps in your understanding of this topic. If you're honestly interested in this topic, you should read some good, entirely non-fiction, published literature on it.


LSD showed me that my logical worldview is breakable with just a little bit of chemistry.

That revelation is real.


Have you read _The Man Who Mistook His Wife for a Hat and Other Clinical Tales_? That was what made me realise how disconnected sensation can be from reality.


I heard about it but didn't read it.

But I knew about different effects of the brain before just that I thought I'm 'different'.

LSD showed me very fast and very clear that this is not the case


objective -strong emphasis-

Where would this come from, other than self-reporting? Plus the claims are typically not about 'efficiency', just that ideas people have had under the influence of LSD have inspired, in some part, their real subsequent work - from all sorts of art to code. There are piles of examples of this.

Don Hopkins a few years ago with a deep dive into Bill Atkinson, Hypercard, LSD and lots of other interesting stuff:

https://news.ycombinator.com/item?id=21783040


> Where would this come from, other than self-reporting?

Presumably all the same labs that already test cognition and creativity?

(I don't know which of the bajillion different meanings of "consciousness" is being used here, but my guess is that that it's one of the vaguer ones that nobody is testing).


Set and setting in a lab experiment is usually not ideal.


>Where would this come from, other than self-reporting?

From competitive pressure in the creative industry? My work isn't good because I think it is. And if LSD did give access to a deeper, higher reality, you'd think LSD users would produce more impactful work.


Not every human experience is supposed to be based on performance, the moment you get away with performance as the utmost objective you will find some freedom.

LSD and other psychedelics give you insights, ways to see things without the noise of your ego always in front of it, and those experiences are valuable to oneself, not necessarily to be more productive, more creative, etc. Many artists used LSD, many other artists are teetotalers, each one has their own experiences to draw from to create their art, it's the sum of the self experience that creates impactful work.

You are looking at this as if life is some sort of competitive sport and people are only trying to gain an edge by taking mind-altering substances, that's not how life works nor a good way to approach those substances. You can't min-max life, as much as you try, that's the illusion of control living in your mind speaking.


LSD users have produced all sorts of impactful work? In general, mind-altering-substance-to-aid/inspire-creativity doesn't feel like some controversial statement that requires citations - we've got everything from shamanism, through the cliche of the drunk writer to Kubla Khan: or A Vision in a Dream, etc, etc. Why would it be different for LSD or be dependent on LSD providing "access to a deeper, higher reality"?


For me LSD is a recreational experience. I don't think it's improved my cognition, creativity or consciousness, and don't know if it's given me any revelations either. What I do know is that taking some every couple weeks makes me happy, and it's fun to talk to friends on it, because the way it makes me think feels satisfying. It just feels nice.

I think the admiration for it is because it's only recently starting to be re-explored by scientists and researchers, and psychedelics are generally very interesting substances (at least in my opinion). On top of that, the culture and history behind them is also quite interesting. The fact that they're currently illegal in the US is quite unfortunate.


Microdosing LSD does wonders to my thoughts. I'm not sure if one can call it "improved cognition" (what does that even mean)


Great for you, but it is with the self-reporting that I have a problem. Is it true or has the drug just altered your evaluation of yourself?

If you read Oliver Sacks' _The Man Who Mistook His Wife for a Hat and Other Clinical Tales_, you'd see that self-perception can be completely off the mark.


Yes, a substance like LSD can alter one's self-evaluation, but that doesn't negate the validity of the experience. LSD and similar substances offer a unique lens, a radical shift in perspective that can unveil new ideas, hidden patterns. If you get a the message, hang up the phone.

In the end, all ideas have to be measured against all other ideas.

But I suppose what you're aiming at here are objective, measurable results in a scientific context? Well, we have a huge hole in the research body of about 45 years, thanks to criminalization (it is very tedious to get a study approved on a schedule 1 drug). However, in recent years, it seems to be opening up. They call it the psychedelic renaissance. Numerous studies have explored both the subjective effects and the applications in mental health. One that strikes out to me involves testing on individuals attempting to quit smoking. After a year, 80% (!) of the participants successfully maintained their cessation from smoking. [1] This is after a single dose!

Long rant, the point is, there are measurable, real-world impacts that these substances can have.

[1] https://pubmed.ncbi.nlm.nih.gov/27441452/


I've been wondering about microdosing myself, since for some reason LSD helps me do showers and other chores that I usually have problems with due to ADHD. I don't know why, though.

What microdosing schedule do you use?


> Because I definitely never see LSD listed in the category of "doping" substances.

Are illegal substances usually listed there? I'd assume they'd only list otherwise legal substances.


Yes they are - under the blanket "non approved substances.

In the other sections, you'll find morphin, heroin, Cannabis derivatives, etc.

https://www.wada-ama.org/en/prohibited-list


people have been trying to measure those effects since the 1950s - Oscar Janiger, James Fadiman, were/are some of the big name researchers trying to quantify it. but it's remarkably hard to measure "creativity".


I would at least have expected an observational data point - doping with LSD, the same way we see widespread doping in many professions (including creative ones) with amphetamines/Adderall. But no, I mostly see use by creatives "stuck in a rut", with a wide gap between what they perceive ("LSD helps me getting more creative", "I had a breakthrough", or the more extreme "it opened my mind to new realities") and objective reality (mediocre work). You don't see "the best works of this artist come from his LSD period".

You see another type/style of work (... usually "psychedelic"). You dont see groundbreaking stuff in the general, universal term, despite all the stuff about "a higher plane of existence", "opening the mind", "being one with the universe".


I think the closest thing I know about is Harman and Fadiman's 1966 study where they gave mescaline to a diverse group of professionals to see if it could help them find creative solutions to problems they were stuck on at work. Apparently it worked! It was meant to be pilot project to launch further study, but instead the research was shut down due to tightening federal restrictions https://journals.sagepub.com/doi/abs/10.2466/pr0.1966.19.1.2...


I found a video of Fadiman discussing it (in the middle of a long rambly talk) https://youtu.be/KtL5fafpRKc?t=538&si=ZyxdmUwSWfubn2UE


Have you considered that, when people reach for LSD while "stuck in a rut", their output should really be measured against that baseline? I mean, going from "I can't do anything" to "I can do mediocre work" is a fairly big improvement.

That said, in general, I would agree that the long-term effects of LSD on one's abilities are not all that profound. What it does, mostly, is making you more aware of things (or rather connections between things), centered on yourself. Whether this actually leads to any improvement depends on what one does with this information, but, well... how many people drastically change their lifestyle after being told by a doctor that they should do so? Same applies here.

As far as doing things during a trip, this can go either way. LSD takes one's "pattern matcher" up to 11, basically. This means that you can easily spot actual patterns that are there that would take you a lot of time in a normal state of mind, but it also means that you start seeing clear patterns in random noise. Since either manifest as intuition, the only reliable way to distinguish them is by rigorous methodical testing, which can be done, but during the trip it's basically swimming against the current, so generally, people don't. The quality of the output then depends on the input (i.e. on whether there was an actual pattern to find or not, and on how much random noise there was in the environment). It's no wonder, then, that this averages out to mediocre.

But I do think that actual quantifiable improvements could be achieved with strict adherence to a "trip protocol" scientifically developed to optimize for that. Those wouldn't be fun trips, though! And, of course, you'd need to develop such a protocol first through study, which is difficult when it's such a tightly controlled substance.


Sorry, my writing isn't as good or clear as I wish: my beef is with the mystique around LSD opening "the gates of reality" - extraordinary,above normal claims. That's why getting from a rut to mediocre when you were once great is not what I had in mind.

Let's be honest: if people have been talking so much about LSD for so long, it is not as an aid to get back to mediocre.


I think you're overly focusing on one particular subset of people talking about LSD. I can assure you that "getting back to normal" is a very common motivation for many, and they do talk about it. It's just not the kind of talk that you see making sensational headlines.

The "gates of reality" stuff is more complicated. Quite a few people interpret it in a very... religious sense. Like your mind literally "connects" to some other place or entities that actually physically exists and can grant one powers. I can totally see how people who are religious, or already into various esoteric spiritual practices, or even just raised in a culture where such themes are common, can have that takeaway from a trip - what they see is their own consciousness reflected, but if they are already primed to believe in such stuff literally, it can be very convincing. But, conversely, there are many people that are perfectly capable of understanding that the ultimate source of all experiences on a trip is one's own mind; "opening the gates" then can metaphorically mean better awareness of oneself and one's interactions with the world at large, but I can't think of any way you'd be able to quantify that externally.


Curious, have you ever tried a psychedelic?


Nope. I was an avid reader of PK Dick - and the coda to _A Scanner Darkly_ was a clear warning that drugs weren't like doping, a trade where your lose your health but gain performance above normal, but a lose-lose proposition - a _miroir aux alouettes_.

Another artist I am extremely fond of, Mœbius (Jean Giraud), also had a very bad time after a failed psychedelic initiation (but my memory may be wrong, as I can't find it in writing on the web - was it in a biographical documentary or am I mixing him with someone else?).

Like Jodorowsky, I never felt I needed drugs - even to enjoy his work, PKD's work or other usually associated with psychedelic use or culture (Aldiss, Lem, Herbert,Zelazny, Bester). When I listen to weird electrical like Aphex Twin or Bicep and people in the comments talk how they seem to need drugs to feel the music kick, I seriously wonder why - I felt there was little to gain for a great risk to take (either from impurities in the substance, or the substance itself - the risk of a bad trip).

In short: I'm abnormal enough? I am clearly more creative than baseline (but less disciplined to really exploit it - and there isn't a drug with the right profile to make one more disciplined yet critical enough to stay on course).

As a sci-fi reader, of course I am very interested in other dimensions, breakthroughs, alien thinking and superpowers. And LSD and others have that mystique - but seem very disappointing in reality, compared to those expectations.


For what it’s worth, your entire comment feels like something I would write - except I have taken these substances at decent levels.

They’re novel experiences but I never found myself able to really care about it, nor do I think they left a lasting impression. Always made me wonder if I was missing something that everyone else gets.

(The war on drugs is dumb as hell and I think they should be legal in so far as individual freedom is concerned)


Yeah, supply issues like lethal substitutes could probably be heavily reduced by making it available at drug stores or whatever. If it's legal and regulated then you won't have to fear getting NBOMe or something in place of real LSD.


In short: You found some famous people you like that support your position, and overstated the risk of "drugs"


If I never saw another psychedelic-related link on Hacker News again it would be too soon (just my opinion)


It beats AI/Musk/Passive Income!/etc. (my opinion)


To each their own, but it’s a fascinating topic that has considerable implications for religion, culture, history, art, science, and health. Worth reading about IMO




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