IMO if your goal is to get up and running fast as a single developer I would suggest that you pick a battle-tested server side framework in a language you already know (Django, Rails, Flask, Laravel, Play, Express, ASP.net, whatever), and use HTMX or its equivalent for the framework you’ve chosen (Hotwire for Rails, Livewire for Laravel, etc.) along with vanilla JS and either Bootstrap or Tailwind for CSS. Keep it simple.
On the other hand, if your goal is to make complex interactive apps, or if you do not want to to launch apps yourself and instead want to be more employable by midsized or large companies, pick up React.
On the other hand, if your goal is to make complex interactive apps, or if you do not want to to launch apps yourself and instead want to be more employable by midsized or large companies, pick up React.