Aren't many of the issues with Jupyter being mentioned in this thread solved by Quarto? I have been advocating for it's use more at work, and NIH has even started offering classes on it through the NIH library.
Exactly my thoughts too, especially regarding reproducibility issues Quarto has been great in the past for projects at my workplace.
I have yet to try Marimo but synchronised code cells are what seems to set it apart. Quarto + jupyter-cache [1] was the closest I have managed to get to that experience but that approach has its constraints.
