I've been using SpamAssassin since, well, forever, in internet terms. My recent facepalm moment was when I noticed that E-mails from the Playdate developer forum (Playdate is a really cool tiny gaming console) land in my spam folder, because anything in the .date domain (and the forum uses play.date as the domain) is assumed to be "dating spam".
I have deny listed most of those new funny tld as it’s indeed a good indication of spam. Here the face palm should be playdate’s because they have realized their domain looks like a spam domain.
Yes, I do the same. It's very useful to me because there is no non-generic TLD that I would be getting legitimate email from, but it may not work well for people who do want to get emails from such TLDs.