On multiple occasions I have responded to a "perfect fit" type message on a tech stack mismatch, only to have it lead to a phone screen where everyone is confused why we're talking.
My current job is primarily using a new-to-me language (C#) on a platform I hadn't used in 10 years (Windows), and though I have some buyers remorse (Windows is still terrible), everybody was on the same page about my skills, I've picked up C# easily enough, and it's worked out fine so far.