While acknowledging that I don't know whether I can tell the difference in every case or not, I would summarize my own preference for lossless audio in the following terms. Choosing lossy audio, my best case scenario is that I save space or bandwidth because I can't tell the difference; my worst case scenario is that I'm missing some element of the music, whether it is consciously noticeable, something I'm unaware of entirely, or perhaps something that I may only be experiencing on a somatic level that doesn't reach the level of conscious thought (I know that the possibility of this last option will be contested by some, and that's fair enough). Choosing lossless audio, my best case scenario is that I'm hearing the music in a higher fidelity, and increasing the amount I'm capable of appreciating; my worst case scenario is that I'm wasting some space or bandwidth for the reassurance. Basically, Pascal's Wager, but for audio.
There are measurably much larger effects from insufficient replication hardware. Are you using the same amp, speakers, room, listening position, and volume level as the person who mastered the recording? No? Then your difference in setup is adding much larger differences than -90 dB RMSE.
It's all a painfully fruitless effort when you learn that most masters don't even consider the phasing of instrument microphones and none of it is at all a close approximation of what it would be like to be in a room listening to instruments. It's good enough, yeah, but there are much more important and difficult threads to tug than lowering noise in the signal chain.
