On: Pharmacokinetics: Drug development's broken stair

[atombender]

Don't know about 10x, but having the MTHFR mutation genotype 667TT reduces folate activation [1] by 70-80%, which is a problem with drugs that require folate supplementation, like methotrexate.

[1] https://www.snpedia.com/index.php/Rs1801133