On: We’re closer to ‘engineering’ blood vessels

[go_prodev]

I'm eagerly awaiting cyclodextrin based treatments, that can potentially remove the plaque and cholesterol buildup.

There's so much to be positive about at the moment.

[tcbawo → go_prodev]

Do you have any links to what you’re referring to? From what I dug up, early results had not shown effectiveness with reversing atherosclerosis.

[go_prodev → tcbawo]

It appears to be a pretty active area of research on Google Scholar, which is where I first learned about Cyclodextrin for heart disease.

Here are some of the links I've read recently, which sound promising to me (a non-expert in this field).

Microarray patches to deal with bio-availability of Cyclodextrin: https://www.sciencedirect.com/science/article/pii/S014486172...

Cholrem company has a commercial product Cavadex, which they claim can reverse arterial plaque: https://www.cholrem.com/

Cyclarity Therapeutics have a Cyclodextrin candidate drug they are hoping to start trials on next year: https://cyclaritytx.com/our-science/

Cyclarity (formerly Underdog Pharmaceuticals) published an article on their technology to use Cyclodextrin molecules to encapsulate "toxic biomolecules" including 7-ketocholesterol which they believe is linked to atherosclerosis and macular degeneration. I think this might be the approach they are using with their candidate drug linked above. https://www.sciencedirect.com/science/article/pii/S037851732...

I get the impression that Cyclodextrins are far from perfect, but at least there is some hope for non-invasive treatments in future.

[forgetfreeman → tcbawo]

According to a thing I read a while back on the AHA website the only thing known to reverse atherosclerosis is interment in a concentration camp. :/

[heyitsguay → forgetfreeman]

Seeking cofounder for a disruptive, high-margin healthcare startup providing new treatments with deep historical roots.

[rpastuszak → heyitsguay]

Keep talking like that and you might end up on the cover of Forbes