On: RNA repair mechanism discovered in humans

[shpongled]

David Sinclair is considered to be a quack (bordering on a fraud) by many within the scientific community.

[meowkit → shpongled]

So I guess we're at the point which Harvard Medical School isn't good signal?

https://sinclair.hms.harvard.edu/people/david-sinclair

Who considers him a quack? Why should I believe them?

[shpongled → meowkit]

The former dean of Harvard Medical School: https://twitter.com/jflier/status/1495833104510038026

A slew of retracted papers from his mentor's lab, and image duplications/fabricated western blots from David's lab:

https://forbetterscience.com/2020/05/14/never-ageing-anti-ag...

https://forbetterscience.com/2023/04/17/the-original-sins-of...

Several blog posts on the resveratrol controversy by Derek Lowe (required reading in pharma/biotech):

https://www.science.org/content/blog-post/resveratrol-srt501...

https://www.science.org/content/blog-post/does-resveratrol-r...

https://www.science.org/content/blog-post/resveratrol-humans...

https://www.science.org/content/blog-post/latest-sirtuin-con...

Also anecdotal, but I personally know several PIs who worked on sirtuins during their PhDs and they all say that David is full of shit.

[vhcr → shpongled]

You're gonna need to backup your claim, because a quick google search didn't lead me to anything.

[altvali → vhcr]

Not the person you're replying to, but this is what I found after a quick google search:

Dr. Jeffrey Flier: https://twitter.com/jflier/status/1495909501211447305?s=21

Dr. Charles Brenner: https://twitter.com/CharlesMBrenner/status/14966040557993615...

Dr. Brad Stanfield: https://www.youtube.com/watch?v=JAFnD27ffqE

[shpongled → vhcr]

See the tweets from the other replier, as well as my reply above.