Mics? Chances are (unless you're a vocalist) you can either DI straight into a plugin or use a VSTi to just midi program a sampled version of your instrument both performed and engineered to a higher standard than you can reach.
While I've certainly done everything in software, there are a lot of genres (such as metal) where micing is a part of the sound. If you listen to metalcore vs a lot of metal, you can hear it.
I would disagree on that, as a hobbyist metal guitarist myself, software like Neural DSP, Bogren etc has made such strides in amp modelling that you can get the same sounds in the box. There are a number of releases I've heard where you simply cannot tell the difference, arguably nor should you bother trying, they sound fantastic.
A lot of amp modeling software allows you to place the mic virtually in different positions because it affects the sound. I think when using a Kemper to profile an amp, it models the microphone + amplifier
I own a copy of bias fx, but I still feel that the nuances of mic positioning and acoustics can give an organic feel easily, much like how good musicians swing beats in an aesthetic way that beat swing plugins don't quite live up to in most cases.
Not everyone has a high opinion of bias fx in comparison to some other modelled amp and cab sims. So that sample size of 1 may not be representative of the current state of the art.