I've been experimenting with home-row combos instead. So you press multiple keys at once, enabling the use of one-shot mods so you don't have to hold keys down for modifiers and can instead tap them
A one-shot shift under one thumb is also amazing, if you have such a keyboard.
With tap-hold functionality, the key behaves the same when tapped, but as the modifier key when held.
So, you can put Shift/Ctrl/Gui/Alt as tap-hold underneath asdf and jkl; on the home row.
This can be achieved on a fancy keyboard, or with cross-platform software like kmonad.